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AR125079A1 - CARBOXY-SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS - Google Patents

CARBOXY-SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS

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Publication number
AR125079A1
AR125079A1ARP220100581AARP220100581AAR125079A1AR 125079 A1AR125079 A1AR 125079A1AR P220100581 AARP220100581 AAR P220100581AAR P220100581 AARP220100581 AAR P220100581AAR 125079 A1AR125079 A1AR 125079A1
Authority
AR
Argentina
Prior art keywords
carboxy
substituted
receptor agonists
glucocorticoid receptor
halogen
Prior art date
Application number
ARP220100581A
Other languages
Spanish (es)
Inventor
Ryan Edward Stites
Jacqueline Mary Wurst
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co ElifiledCriticalLilly Co Eli
Publication of AR125079A1publicationCriticalpatent/AR125079A1/en

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Abstract

Translated fromSpanish

La presente invención proporciona un compuesto de fórmula (1) en donde R¹ es H, halógeno, alquilo C₁-C₃ o alcoxi C₁-C₃; R² es H o halógeno; y X es O, OCH₂ o CH₂, o una sal aceptable desde el punto de vista farmacéutico del mismo, en donde el compuesto de fórmula (1), o una sal aceptable desde el punto de vista farmacéutico del mismo, es útil para tratar enfermedades autoinmunitarias e inflamatorias, tales como dermatitis atópica, artritis reumatoide y nefritis lúpica.The present invention provides a compound of formula (1) wherein R¹ is H, halogen, C₁-C₃ alkyl or C₁-C₃ alkoxy; R² is H or halogen; and X is O, OCH₂ or CH₂, or a pharmaceutically acceptable salt thereof, wherein the compound of formula (1), or a pharmaceutically acceptable salt thereof, is useful for treating diseases autoimmune and inflammatory, such as atopic dermatitis, rheumatoid arthritis, and lupus nephritis.

ARP220100581A2021-03-232022-03-14 CARBOXY-SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTSAR125079A1 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
US202163164592P2021-03-232021-03-23

Publications (1)

Publication NumberPublication Date
AR125079A1true AR125079A1 (en)2023-06-07

Family

ID=81328659

Family Applications (1)

Application NumberTitlePriority DateFiling Date
ARP220100581AAR125079A1 (en)2021-03-232022-03-14 CARBOXY-SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS

Country Status (15)

CountryLink
US (2)US11618767B2 (en)
EP (1)EP4314004B1 (en)
JP (1)JP7598484B2 (en)
KR (1)KR20230148222A (en)
CN (1)CN116888137B (en)
AR (1)AR125079A1 (en)
AU (1)AU2022245209B2 (en)
BR (1)BR112023016268A2 (en)
CA (1)CA3212778A1 (en)
ES (1)ES3017809T3 (en)
IL (1)IL305241A (en)
MX (1)MX2023011280A (en)
TW (1)TWI837613B (en)
WO (1)WO2022204099A1 (en)
ZA (1)ZA202307999B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
EP4393937A1 (en)*2021-08-262024-07-03Duality Biologics (Suzhou) Co., Ltd.Steroid compound and conjugate thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN101227912A (en)2005-06-142008-07-23基利得科学公司Substituted phenylphosphates as mutual prodrugs of steroids and beta-agonists for the treatment of pulmonary inflammation and bronchoconstriction
KR101295998B1 (en)2007-11-302013-08-13화이자 리미티드Novel glucocorticoid receptor agonists
WO2009085879A2 (en)2007-12-212009-07-09Schering CorporationC20-c21 substituted glucocorticoid receptor agonists
US20110294766A1 (en)2008-02-272011-12-01Astrazeneca Ab16 Alpha, 17 Alpha-Acetal Glucocorticosteroidal Derivatives and their Use
EP3359194A4 (en)2015-10-062019-04-24Merck Sharp & Dohme Corp. ANTIBODY-MEDICINAL CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
EP3407916B1 (en)2016-01-292023-12-20Merck Sharp & Dohme LLCPhosphonate linkers and their use to facilitate cellular retention of compounds
HRP20210924T1 (en)*2016-06-022021-09-03Abbvie Inc. GLUCOCORTICOID RECEPTOR AGONIST AND ITS IMMUNOCONJUGATES
WO2018089373A2 (en)*2016-11-082018-05-17Regeneron Pharmaceuticals, Inc.Steroids and protein-conjugates thereof
SI3658192T1 (en)*2017-12-012021-08-31Abbvie Inc.Glucocorticoid receptor agonist and immunoconjugates thereof
SG11202004865SA (en)2017-12-012020-06-29Abbvie IncAnti-cd40 antibody drug conjugates
US20230310634A1 (en)2020-04-222023-10-05Immunext, Inc.Anti-human vista antibodies and use thereof

Also Published As

Publication numberPublication date
CN116888137B (en)2025-08-26
WO2022204099A1 (en)2022-09-29
JP7598484B2 (en)2024-12-11
JP2024510640A (en)2024-03-08
ES3017809T3 (en)2025-05-13
EP4314004A1 (en)2024-02-07
US11618767B2 (en)2023-04-04
US12162905B2 (en)2024-12-10
IL305241A (en)2023-10-01
CN116888137A (en)2023-10-13
US20230227493A1 (en)2023-07-20
BR112023016268A2 (en)2023-10-03
CA3212778A1 (en)2022-09-29
EP4314004B1 (en)2025-01-22
KR20230148222A (en)2023-10-24
TW202304463A (en)2023-02-01
AU2022245209A1 (en)2023-09-07
MX2023011280A (en)2023-10-04
ZA202307999B (en)2025-02-26
AU2022245209B2 (en)2024-03-07
US20220306681A1 (en)2022-09-29
TWI837613B (en)2024-04-01

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