Adaptive optimal two-stage designs for clinical trials with one or two arms. For details on the core theoretical background, see:
Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs.Statistics in Medicine. 2019;38(21):4159–4171.https://doi.org/10.1002/sim.8291
Installation
Install the latest CRAN release via
install.packages("adoptr")and the development version directly fromGitHub with:
devtools::install_github("optad/adoptr")Documentation
The documentation is hosted athttps://optad.github.io/adoptr.
Validation Report
We provide an extensive validation report foradoptr which is implemented using thebookdown package. The sources are available athttps://github.com/optad/adoptr-validation-report and the last build version is hosted athttps://optad.github.io/adoptr-validation-report.
