HGNC Approved Gene Symbol:TXLNA
Cytogenetic location:1p35.2 Genomic coordinates(GRCh38) :1:32,179,675-32,198,285 (from NCBI)
Using a blot overlay technique to identify proteins from rat lung that interact with the SNARE membrane protein Stx3 (600876),Nogami et al. (2003) identified Txln. By searching databases using peptide sequences of purified rat Txln, followed by RACE of a brain cDNA library, they cloned human TXLN. The predicted TXLN protein contains 546 amino acids and has a calculated molecular mass of 62 kD. It has a long C-terminal coiled-coil domain, 24 potential phosphorylation sites, 1 N-glycosylation site, 10 N-myristoylation sites, and 3 EF-hand motifs. Northern blot analysis detected a major 5.1-kb TXLN transcript in all tissues tested, as well as 2.1- and 1.5-kb TXLN transcripts in heart, liver, and pancreas.
Using coimmunoprecipitation experiments,Nogami et al. (2003) showed that TXLN interacts with STX3 through its coiled-coil domain. They found that TXLN also interacts with STX1A (186590) and STX4 (186591). Immunofluorescence and confocal microscopy demonstrated that coexpression of TXLN with STX4 caused relocalization of TXLN from the cytosol to the plasma membrane. Overexpression of TXLN in PC12 cells inhibited human growth hormone (139250) exocytosis in response to high potassium levels.
Nogami, S., Satoh, S., Nakano, M., Shimizu, H., Fukushima, H., Maruyama, A., Terano, A., Shirataki, H.Taxilin; a novel syntaxin-binding protein that is involved in Ca(2+)-dependent exocytosis in neuroendocrine cells. Genes Cells 8: 17-28, 2003. [PubMed:12558796,related citations] [Full Text]
Alternative titles; symbols
HGNC Approved Gene Symbol: TXLNA
Cytogenetic location: 1p35.2 Genomic coordinates(GRCh38) : 1:32,179,675-32,198,285(from NCBI)
Using a blot overlay technique to identify proteins from rat lung that interact with the SNARE membrane protein Stx3 (600876), Nogami et al. (2003) identified Txln. By searching databases using peptide sequences of purified rat Txln, followed by RACE of a brain cDNA library, they cloned human TXLN. The predicted TXLN protein contains 546 amino acids and has a calculated molecular mass of 62 kD. It has a long C-terminal coiled-coil domain, 24 potential phosphorylation sites, 1 N-glycosylation site, 10 N-myristoylation sites, and 3 EF-hand motifs. Northern blot analysis detected a major 5.1-kb TXLN transcript in all tissues tested, as well as 2.1- and 1.5-kb TXLN transcripts in heart, liver, and pancreas.
Using coimmunoprecipitation experiments, Nogami et al. (2003) showed that TXLN interacts with STX3 through its coiled-coil domain. They found that TXLN also interacts with STX1A (186590) and STX4 (186591). Immunofluorescence and confocal microscopy demonstrated that coexpression of TXLN with STX4 caused relocalization of TXLN from the cytosol to the plasma membrane. Overexpression of TXLN in PC12 cells inhibited human growth hormone (139250) exocytosis in response to high potassium levels.
Nogami, S., Satoh, S., Nakano, M., Shimizu, H., Fukushima, H., Maruyama, A., Terano, A., Shirataki, H.Taxilin; a novel syntaxin-binding protein that is involved in Ca(2+)-dependent exocytosis in neuroendocrine cells. Genes Cells 8: 17-28, 2003. [PubMed: 12558796] [Full Text: https://doi.org/10.1046/j.1365-2443.2003.00612.x]
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