HGNC Approved Gene Symbol:GPR119
Cytogenetic location:Xq26.1 Genomic coordinates(GRCh38) :X:130,379,449-130,385,674 (from NCBI)
GPR119 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).
By searching databases for GPRs containing no introns in the coding region,Takeda et al. (2002) identified GPR119, which they designated GPCR2. The deduced protein shares 27% homology with dopamine receptor-1 (see126449). RT-PCR detected ubiquitous GPR119 expression.
By searching databases for sequences similar to rhodopsin-like GPRs,Fredriksson et al. (2003) identified mouse and human GPR119. The deduced 335-amino acid proteins assume a classic 7-transmembrane (TM) topology and share 82% amino acid identity. They contain the characteristic DRY motif in the intracellular side of TM3 and an NSxxNPxxY motif in TM7.
Takeda et al. (2002) andFredriksson et al. (2003) determined that the coding regions of the mouse and human GPR119 genes are derived from a single exon.
By genomic sequence analysis,Fredriksson et al. (2003) mapped the GPR119 gene to chromosome Xq26.1. They mapped the mouse Gpr119 gene to the X chromosome.
Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B.Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed:14623098,related citations] [Full Text]
Takeda, S., Kadowaki, S., Haga, T., Takaesu, H., Mitaku, S.Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 520: 97-101, 2002. Note: Erratum: FEBS Lett. 523: 257 only, 2002. [PubMed:12044878,related citations] [Full Text]
Alternative titles; symbols
HGNC Approved Gene Symbol: GPR119
Cytogenetic location: Xq26.1 Genomic coordinates(GRCh38) : X:130,379,449-130,385,674(from NCBI)
GPR119 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).
By searching databases for GPRs containing no introns in the coding region, Takeda et al. (2002) identified GPR119, which they designated GPCR2. The deduced protein shares 27% homology with dopamine receptor-1 (see 126449). RT-PCR detected ubiquitous GPR119 expression.
By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified mouse and human GPR119. The deduced 335-amino acid proteins assume a classic 7-transmembrane (TM) topology and share 82% amino acid identity. They contain the characteristic DRY motif in the intracellular side of TM3 and an NSxxNPxxY motif in TM7.
Takeda et al. (2002) and Fredriksson et al. (2003) determined that the coding regions of the mouse and human GPR119 genes are derived from a single exon.
By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR119 gene to chromosome Xq26.1. They mapped the mouse Gpr119 gene to the X chromosome.
Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B.Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098] [Full Text: https://doi.org/10.1016/s0014-5793(03)01196-7]
Takeda, S., Kadowaki, S., Haga, T., Takaesu, H., Mitaku, S.Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 520: 97-101, 2002. Note: Erratum: FEBS Lett. 523: 257 only, 2002. [PubMed: 12044878] [Full Text: https://doi.org/10.1016/s0014-5793(02)02775-8]
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