HGNC Approved Gene Symbol:CD1E
Cytogenetic location:1q23.1 Genomic coordinates(GRCh38) :1:158,353,894-158,357,553 (from NCBI)
CD1E is a group 1 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. See CD1A (188370) andPark and Bendelac (2000) for background on CD1 molecules.
The 5 CD1 genes have been shown to be linked (Yu and Milstein, 1989) on human chromosome 1q21-q23 (Albertson et al., 1988).
De la Salle et al. (2005) demonstrated that the mycobacterial antigens hexamannosylated phosphatidyl-myo-inositols (PIM6) stimulate CD1B (188360)-restricted T cells only after partial digestion of the oligomannose moiety by lysosomal alpha-mannosidase and that soluble CD1E is required for this processing. Furthermore, recombinant CD1E was able to bind glycolipids and assist in the digestion of PIM6.De la Salle et al. (2005) proposed that through this form of glycolipid editing, CD1E helps to expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune responses.
Albertson, D. G., Fishpool, R., Sherrington, P., Nacheva, E., Milstein, C.Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J. 7: 2801-2805, 1988. [PubMed:3053166,related citations] [Full Text]
de la Salle, H., Mariotti, S., Angenieux, C., Gilleron, M., Garcia-Alles, L.-F., Malm, D., Berg, T., Paoletti, S., Maitre, B., Mourey, L., Salamero, J., Cazenave, J. P., Hanau, D., Mori, L., Puzo, G., De Libero, G.Assistance of microbial glycolipid antigen processing by CD1e. Science 310: 1321-1324, 2005. [PubMed:16311334,related citations] [Full Text]
Park, S.-H., Bendelac, A.CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000. [PubMed:10963609,related citations] [Full Text]
Yu, C. Y., Milstein, C.A physical map linking the five CD1 human thymocyte differentiation antigen genes. EMBO J. 8: 3727-3732, 1989. [PubMed:2583117,related citations] [Full Text]
HGNC Approved Gene Symbol: CD1E
Cytogenetic location: 1q23.1 Genomic coordinates(GRCh38) : 1:158,353,894-158,357,553(from NCBI)
CD1E is a group 1 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. See CD1A (188370) and Park and Bendelac (2000) for background on CD1 molecules.
The 5 CD1 genes have been shown to be linked (Yu and Milstein, 1989) on human chromosome 1q21-q23 (Albertson et al., 1988).
De la Salle et al. (2005) demonstrated that the mycobacterial antigens hexamannosylated phosphatidyl-myo-inositols (PIM6) stimulate CD1B (188360)-restricted T cells only after partial digestion of the oligomannose moiety by lysosomal alpha-mannosidase and that soluble CD1E is required for this processing. Furthermore, recombinant CD1E was able to bind glycolipids and assist in the digestion of PIM6. De la Salle et al. (2005) proposed that through this form of glycolipid editing, CD1E helps to expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune responses.
Albertson, D. G., Fishpool, R., Sherrington, P., Nacheva, E., Milstein, C.Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J. 7: 2801-2805, 1988. [PubMed: 3053166] [Full Text: https://doi.org/10.1002/j.1460-2075.1988.tb03135.x]
de la Salle, H., Mariotti, S., Angenieux, C., Gilleron, M., Garcia-Alles, L.-F., Malm, D., Berg, T., Paoletti, S., Maitre, B., Mourey, L., Salamero, J., Cazenave, J. P., Hanau, D., Mori, L., Puzo, G., De Libero, G.Assistance of microbial glycolipid antigen processing by CD1e. Science 310: 1321-1324, 2005. [PubMed: 16311334] [Full Text: https://doi.org/10.1126/science.1115301]
Park, S.-H., Bendelac, A.CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000. [PubMed: 10963609] [Full Text: https://doi.org/10.1038/35021233]
Yu, C. Y., Milstein, C.A physical map linking the five CD1 human thymocyte differentiation antigen genes. EMBO J. 8: 3727-3732, 1989. [PubMed: 2583117] [Full Text: https://doi.org/10.1002/j.1460-2075.1989.tb08548.x]
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