National Institute of Siddha (NIS) is located alongside Grand South Trunk Road (GST road) at Tambaram Sanatorium in Chennai. It is at a distance of about 6 km from Chennai Airport, about 24 km from Chennai Central Railway Station, just 2 km from Tambaram Railway Station and about 100 Meters from Tambaram Sanatorium Railway Station. It is about 13 km from The Tamil Nadu Dr. MGR Medical University to which it is affiliated.