Transforming growth factor beta (TGFβ) receptors aresingle passserine/threonine kinase receptors that belong toTGFβ receptor family. They exist in several differentisoforms that can behomo- orheterodimeric.^[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between theligand and receptor interactions.

TGFβ is agrowth factor andcytokine involved inparacrine signalling and can be found in many differenttissue types, includingbrain,heart,kidney,liver,bone, andtestes. Over-expression of TGFβ can induce renalfibrosis, causingkidney disease, as well asdiabetes, and ultimatelyend-stage renal disease. Recent developments have found that, using certain types of proteinantagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.^{[citation needed]}

Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties.TGFβR1 (ALK5) andTGFβR2 have similar ligand-binding affinities and can be distinguished from each other only bypeptide mapping. Both TGFβR1 and TGFβR2 have a high affinity forTGFβ1 and low affinity forTGFβ2.TGFβR3 (β-glycan) has a high affinity for bothhomodimeric TGFβ1 and TGFβ2 and in addition theheterodimer TGF-β1.2.^[2] The TGFβ receptors also bindTGFβ3.

See also

• TGFβ superfamily receptor
• TGFβ signaling pathway
• TGFβ superfamily

References

External links

• TGF-beta+Receptors at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article about a biochemicalreceptor is astub. You can help Wikipedia byexpanding it.

• v
• t
• e