Silandrone

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Chemical compound
Pharmaceutical compound
Silandrone
Clinical data
Other namesTestosterone 17β-trimethylsilyl ether; TestosteroneO-trimethylsilyl ether; 17β-Trimethylsilyltestosterone;O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
Routes of
administration		By mouth,intramuscular injection,subcutaneous injection
Identifiers
  • (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-17-trimethylsilyloxy-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.023.414Edit this at Wikidata
Chemical and physical data
FormulaC22H36O2Si
Molar mass360.613 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O[Si](C)(C)C)CCC4=CC(=O)CC[C@]34C
  • InChI=1S/C22H36O2Si/c1-21-12-10-16(23)14-15(21)6-7-17-18-8-9-20(24-25(3,4)5)22(18,2)13-11-19(17)21/h14,17-20H,6-13H2,1-5H3/t17-,18-,19-,20-,21-,22-/m0/s1
  • Key:HNZDTAXZHUDITM-WLNPFYQQSA-N

Silandrone (INNTooltip International Nonproprietary Name,USANTooltip United States Adopted Name) (developmental code nameSC-16148), also known astestosterone 17β-trimethylsilyl ether or17β-trimethylsilyltestosterone, as well as17β-(trimethylsiloxy)androst-4-en-3-one, is asyntheticanabolic-androgenic steroid (AAS) and anandrogen ether – specifically, the 17β-trimethylsilylether oftestosterone – which was developed by theG. D. Searle & Company in the 1960s but was never marketed.[1] It has a very longduration of action when given viasubcutaneous orintramuscular injection, as well as significantly greaterpotency than that oftestosterone propionate.[2][3] In addition, silandrone, unliketestosterone and mostesters of testosterone like testosterone propionate, isorally active.[4]

See also

References

  1. ^J. Elks (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–.ISBN 978-1-4757-2085-3.
  2. ^Saunders FJ (November 1966). "A singularly long-acting ether of testosterone".Proceedings of the Society for Experimental Biology and Medicine.123 (2):303–4.doi:10.3181/00379727-123-31472.PMID 5951069.S2CID 21363508.
  3. ^Le Boeuf BJ, Allen JL (1970). "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148".Hormones and Behavior.1 (2):121–125.doi:10.1016/0018-506X(70)90004-8.
  4. ^Chinn LJ (1969).The Chemistry and Biochemistry of Steroids. Geron-X. p. 97.ISBN 9780876720035.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists


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