Protein-coding gene in the species Homo sapiens
Interleukin 20receptor , alpha subunit , is asubunit of theinterleukin-20 receptor , theinterleukin-26 receptor, and theinterleukin-24 receptor.[ 5] IL20R1 [ 6] IL20RA. [ 7] JAK-STAT pathway .[ 5]
Tissue distribution IL20RA is found in the skin,lungs ,ovaries ,testes andplacenta , with lowgene expression in theintestine andliver .[ 7] effector cells such askeratinocytes at the skin epidermis,osteoclasts , found in bones, andepithelial cells of the intestine andtrachea . IL20RA is also found in someimmune cells.[ 8]
Structure and function IL20RA is an alpha-chain with a long intracellular domain. IL20RA, along with the IL-20 receptor, beta subunit, form theheterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26.[ 5]
Signaling Receptors made up of IL20RA signal through aJAK-STAT signaling pathway .[ 5] intracellular domains of IL20R activate andphosphorylate tyrosine residues found in the longer alpha chains of IL20RA. STAT then binds to docking sites created by JAK phosphorylation and becomes phosphorylated by JAK. STATs then dimerize and move to the nucleus to act as transcription factors. The specific genes expressed are dependent on the specific JAK, STAT, as well as bySOCS proteins , which can inhibit the JAK-STAT signal, regulating it.where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.[1] IL20RA has multiple docking sites for STAT3.[ 5] [ 9]
Clinical significance Research indicates that IL20RA is found in some immune cells. For example, IL20RA is sometimes found in lungmacrophages . Research indicates that IL20RA presence may be related to disease. In people withrheumatoid arthiritis , IL20RA is present in bloodmonocytes .[ 8]
IL20RA has also been linked withpsoriasis , andatherosclerosis , all diseases associated with inflammation. The specific role of IL20RA in these diseases is unknown.[ 7]
References ^a b c GRCh38: Ensembl release 89: ENSG00000016402 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000020007 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^a b c d e Wegenka UM (2010-10-01)."IL-20: Biological functions mediated through two types of receptor complexes" Cytokine & Growth Factor Reviews . IL-10 Family of Cytokines.21 (5):353– 363.doi :10.1016/j.cytogfr.2010.08.001 .ISSN 1359-6101 .PMID 20864382 . ^ Wirtz MK, Keller KE (2016)."The Role of the IL-20 Subfamily in Glaucoma" .Mediators of Inflammation .2016 : 4083735.doi :10.1155/2016/4083735 ISSN 0962-9351 .PMC 4745377 PMID 26903709 . ^a b c Rutz S, Wang X, Ouyang W (December 2014)."The IL-20 subfamily of cytokines — from host defence to tissue homeostasis" Nature Reviews. Immunology .14 (12):783– 795.doi :10.1038/nri3766 .ISSN 1474-1741 .PMID 25421700 .S2CID 29114703 . ^a b Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25)."The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis" .Frontiers in Immunology .9 : 2226.doi :10.3389/fimmu.2018.02226 ISSN 1664-3224 .PMC 6167463 PMID 30319661 . ^ Blumberg H, Conklin D, Xu W, Grossmann A, Brender T, Carollo S, et al. (2001-01-12)."Interleukin 20: Discovery, Receptor Identification, and Role in Epidermal Function" .Cell .104 (1):9– 19.doi :10.1016/S0092-8674(01)00187-8 ISSN 0092-8674 .PMID 11163236 .
Further reading Bonaldo MF, Lennon G, Soares MB (Sep 1996)."Normalization and subtraction: two approaches to facilitate gene discovery" .Genome Research .6 (9):791– 806.doi :10.1101/gr.6.9.791 PMID 8889548 . Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, Wood W, et al. (Oct 2000)."Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R" .Journal of Biological Chemistry .275 (40):31335– 31339.doi :10.1074/jbc.M005304200 PMID 10875937 . Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, et al. (Jan 2001)."Interleukin 20: discovery, receptor identification, and role in epidermal function" .Cell .104 (1):9– 19.doi :10.1016/S0092-8674(01)00187-8 PMID 11163236 .S2CID 7460710 . Leemans C, Lejeune D, Kotenko S, Renauld J, Dumoutier L (Oct 2001)."Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types" .Journal of Immunology .167 (7). Baltimore, Md.:3545– 3549.doi :10.4049/jimmunol.167.7.3545 PMID 11564763 . Tan Z, Zhang R, Kotenko S, Liang P, Wang M (Mar 2002)."Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2" .Journal of Biological Chemistry .277 (9):7341– 7347.doi :10.1074/jbc.M106043200 PMID 11706020 . Xu W, Brender T, Yao L, Jones C, West J, Brandt C, et al. (Dec 2002)."Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions" .Journal of Biological Chemistry .277 (49):47517– 47523.doi :10.1074/jbc.M205114200 PMID 12351624 . Feingold EA, Grouse LH, Derge J, Klausner R, Collins F, Wagner L, et al. (Dec 2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proceedings of the National Academy of Sciences of the United States of America .99 (26):16899– 16903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, et al. (Oct 2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" .Genome Research .13 (10):2265– 2270.doi :10.1101/gr.1293003 .PMC 403697 PMID 12975309 . Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, et al. (Oct 2003)."The DNA sequence and analysis of human chromosome 6" .Nature .425 (6960):805– 811.Bibcode :2003Natur.425..805M .doi :10.1038/nature02055 PMID 14574404 . Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A, Zdanov A, et al. (Nov 2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20".Biochemistry .42 (43):12617– 12624.doi :10.1021/bi0354583 .PMID 14580208 . Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, et al. (Jan 2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs" .Nature Genetics .36 (1):40– 45.doi :10.1038/ng1285 PMID 14702039 . Baurin VV, Lewis-Antes A, Shah N, Smirnov S, Anantha S, Dickensheets H, et al. (Feb 2004)."Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2" .Journal of Immunology .172 (4). Baltimore, Md.:2006– 2010.doi :10.4049/jimmunol.172.4.2006 hdl :2078.1/83944 PMID 14764663 . Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld J, et al. (Aug 2004)."The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains" .Journal of Biological Chemistry .279 (32):33343– 33351.doi :10.1074/jbc.M405000200 PMID 15178681 . Zhang Z, Henzel WJ (Oct 2004)."Signal peptide prediction based on analysis of experimentally verified cleavage sites" .Protein Science .13 (10):2819– 2824.doi :10.1110/ps.04682504 .PMC 2286551 PMID 15340161 .
