Esophageal candidiasis
Other names: Candidal esophagitis, monilial esophagitis
A severe case of esophageal candidiasis
Specialty	Infectious disease

Esophageal candidiasis is anopportunistic infection of theesophagus byCandida albicans.

The disease usually occurs in people inimmunocompromised states, including post-chemotherapy and inAIDS. However, it can also occur in those with no predisposing risk factors, and is more likely to be asymptomatic in this case.^[1]

Signs and symptoms

People with esophageal candidiasis typically present withdifficult orpainful swallowing. Longstanding esophageal candidiasis can result inweight loss. There is often concomitantthrush in the mouth.

Some patients present with esophageal candidiasis as a first presentation of systemiccandidiasis.

Risk factor

The risk factors of Esophageal candidiasis which is an opportunistic infection in immunosuppressed individuals are:^[2]

• HIV positive and AIDS
• Chemotherapy
• Antibiotic therapy
• Topical inhaledcorticosteroids

Diagnosis

In most cases, the diagnosis is established based on response to therapy. Patients in whom esophageal candidiasis is suspected should receive a brief course of antifungal therapy withfluconazole. If the infection resolves after treatment withfluconazole, then the diagnosis of esophageal candidiasis is made and no further investigation is needed. However, if the infection persists or if there are other factors involved which may warrant further investigation, then patient will undergo anesophagogastroduodenoscopy if it is safe to do so. Endoscopy often reveals classic diffuse raised plaques that characteristically can be removed from themucosa by the endoscope. Brushing orbiopsy of the plaques showsyeast andpseudohyphae byhistology that are characteristic ofCandida species.

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  Esophageal candidiasis stained by periodic acid-Schiff procedure

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  Esophageal candidiasis stained by periodic acid-Schiff procedure

Treatment

The first-line treatment isfluconazole, 200 mg on the first day, followed by daily dosing of 100 mg. for at least 21 days total. Treatment should continue for 14 days after relief of symptoms.Other therapy options include:

• Nystatin is an effective treatment for mild esophageal candidiasis.^[3] It can be used as (swish, do not swallow) treatment for oral candidiasis that occurs with the use of asthma pumps.
• Suspected cases of esophageal candidiasis should be treated with short-term fluconazole antifungal therapy. When symptoms recover after therapy, we can diagnosis esophageal candidiasis and do not need more investigations.^[4] Oral fluconazole is most commonly used medication for esophageal candididasis. For patients who cannot tolerate oral medication, IV fluconazole can be used alternatively.^[4]
• Other oraltriazoles, such asitraconazole andvoriconazole can be other options.^[4]
• Amphotericin B can be used in nonresponsive cases, but should not be used routinely due to its serious side effects.^[4]
• Posaconazole is effective in severe and refractory esophageal candidiasis.^[4]

References

External links

• Pages with script errors
• Animal fungal diseases
• Esophagus disorders