Ascrinvacumab

From WikiProjectMed

Chemical compound

Pharmaceutical compound

Ascrinvacumab
Monoclonal antibody
Type	?
Source	Human
Target	activin receptor-like kinase 1
Clinical data
Other names	PF-03446962
ATC code	none
Identifiers
CAS Number	1463459-96-2
ChemSpider	none
UNII	716FQ5REVO
KEGG	D11709
Chemical and physical data
Formula	C₆₃₉₆H₉₈₅₀N₁₆₉₄O₂₀₁₂S₄₄
Molar mass	144079.64 g·mol⁻¹

Ascrinvacumab (PF-03446962) is a monoclonal antibody designed for the treatment of cancer.^[1]

This drug was developed byPfizer Inc.

References

^Statement On A Nonproprietary Name Adopted By The USAN Council - Ascrinvacumab,American Medical Association.

Monoclonal antibodies for tumors

Tumor

Human	Adecatumumab^§ Amivantamab Ascrinvacumab^§ Atezolizumab (+hyaluronidase) Balstilimab^† Botensilimab Cixutumumab^§ Conatumumab^§ Cosibelimab Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Flanvotumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Icrucumab^§ Lexatumumab^§ Linvoseltamab Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvacumab^§ Nivolumab^# (+hyaluronidase,+relatlimab) Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Sugemalimab Tarextumab^§ Tisotumab vedotin Teprotumumab^† Tovetumab^§ Vantictumab^§ Votumumab^§ Zalutumumab^†
Mouse	Abagovomab Altumomab pentetate Anatumomab mafenatox Arcitumomab Bectumomab Blinatumomab Capromab pendetide Detumomab Edrecolomab Ibritumomab tiuxetan Igovomab Lilotomab Minretumomab Mitumomab Nacolomab tafenatox Moxetumomab pasudotox Naptumomab estafenatox Oregovomab Pemtumomab^† Racotumomab Satumomab pendetide Solitomab Taplitumomab paptox Nofetumomab merpentan Pintumomab Tenatumomab Tositumomab
Chimeric	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Carotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ecromeximab^§ Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab Mirvetuximab soravtansine Rituximab^# Siltuximab Ublituximab Zolbetuximab
Humanized	Abituzumab^§ Alemtuzumab Axatilimab Belantamab mafodotin Bevacizumab Bivatuzumab mertansine^§ Brontictuzumab^§ Cantuzumab mertansine^§ Cantuzumab ravtansine^§ Cirmtuzumab Citatuzumab bogatox^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Datopotamab deruxtecan Denintuzumab mafodotin^§ Elotuzumab Emactuzumab Emibetuzumab^§ Enoblituzumab^§ Epcoritamab Etaracizumab^§ Farletuzumab^§ Ficlatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab^§ Inotuzumab ozogamicin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansine^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Odronextamab Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatox^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Sofituzumab vedotin^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# (+deruxtecan /+emtansine) Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ Zenocutuzumab
Rat/mouse hybrid	Catumaxomab Ertumaxomab^§
Chimeric + humanized	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Thismonoclonal antibody–related article is astub. You can help Wikipedia byexpanding it.

Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems

Bone

Human	Burosumab Denosumab
Humanized	Blosozumab^† Romosozumab

Musculoskeletal

Human	Stamulumab^†

Circulatory

Human	Abelacimab Alirocumab Ascrinvacumab^§ Bentracimab^† Enoticumab Evinacumab Evolocumab Icrucumab Inclacumab Marstacimab Nesvacumab Orticumab Ramucirumab Rinucumab
Mouse	Biciromab^‡ Imciromab^‡
Chimeric	Abciximab Volociximab
Humanized	Alacizumab pegol Bevacizumab/Ranibizumab Bococizumab Brolucizumab Caplacizumab Concizumab Demcizumab Emicizumab Etaracizumab Faricimab Idarucizumab Ralpancizumab Tadocizumab Vanucizumab

Neurologic

Human	Anti-amyloid drugs Aducanumab^‡ Donanemab Gantenerumab^† Lecanemab Erenumab Fasinumab^† Fulranumab Opicinumab
Humanized	Bapineuzumab^† Crenezumab^† Eptinezumab Fremanezumab Galcanezumab Ozanezumab Ponezumab Refanezumab Semorinemab Solanezumab Tanezumab^†

Angiogenesis inhibitor

Humanized	Ranibizumab

Growth factor

Human	Bimagrumab Trevogrumab
Humanized	Domagrozumab Landogrozumab

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

TGFβ receptor superfamily modulators

Type I

ALK1 (ACVRL1)	Agonists:Activin (A,B,AB) Avotermin BMP (10) Cetermin GDF (2 (BMP9)) TGFβ (1,2,3) Antibodies:Ascrinvacumab Kinase inhibitors:K-02288 ML-347 (LDN-193719, VU0469381) Decoy receptors:Dalantercept Other inhibitors:Disitertide
ALK2 (ACVR1A)	Agonists:Activin (A,B,AB) AMH (MIS) Avotermin BMP (5,6,7,8A,8B) Eptotermin alfa TGFβ (1,2,3) Kinase inhibitors:DMH-1 DMH-2 Dorsomorphin (BML-275) K-02288 ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)	Agonists:AMH (MIS) BMP (2,4,5,6,7,8A,8B) Dibotermin alfa Eptotermin alfa Kinase inhibitors:DMH-2 Dorsomorphin (BML-275) K-02288
ALK4 (ACVR1B)	Agonists:Activin (A,B,AB) GDF (1,3,11 (BMP11)) Myostatin (GDF8) Nodal Antagonists:Inhibin (A,B) Lefty (1,2) Kinase inhibitors:A 83-01 SB-431542 SB-505124
ALK5 (TGFβR1)	Agonists:Avotermin GDF (10 (BMP3B),11 (BMP11)) TGFβ (1,2,3) Antibodies:Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors:A 83-01 D-4476 GW-788388 LY-364947 LY-2109761 Galunisertib (LY-2157299) R-268712 RepSox (E-616452, SJN-2511) SB-431542 SB-505124 SB-525334 SD-208
ALK6 (BMPR1B)	Agonists:BMP (2,4,5,6,7,8A,8B,15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (5 (BMP14),6 (BMP13),7 (BMP12),9,15) Radotermin Kinase inhibitors:DMH-2 Dorsomorphin (BML-275) K-02288
ALK7 (ACVR1C)	Agonists:GDF (1,3,11 (BMP11)) Nodal Antagonists:Lefty (1,2) Kinase inhibitors:A 83-01 SB-431542 SB-505124

Type II

TGFβR2	Agonists:Avotermin GDF (10 (BMP3B)) TGFβ (1,2,3) Antibodies:Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors:DMH-2 LY-364947
BMPR2	Agonists:BMP (2,4,6,7,10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9),5 (BMP14),6 (BMP13),7 (BMP12)) Radotermin Antagonists:Inhibin (A,B)
ACVR2A (ACVR2)	Agonists:Activin (A,B,AB) BMP (2,4,5,6,7,8A,8B,15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (1,3,5 (BMP14),6 (BMP13),7 (BMP12),9,11 (BMP11),15) Myostatin (GDF8) Nodal Radotermin Antagonists:Inhibin (A,B) Lefty (1,2) Decoy receptors:Sotatercept
ACVR2B	Agonists:Activin (A,B,AB) BMP (2,4,6,7) Dibotermin alfa Eptotermin alfa GDF (1,3,5 (BMP14),6 (BMP13),7 (BMP12)) Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin Antagonists:Inhibin (A,B) Lefty (1,2) Decoy receptors:Ramatercept
AMHR2 (AMHR)	Agonists:AMH (MIS)

Type III

TGFβR3 (β-glycan)	Ligands:Avotermin Inhibin (A,B) TGFβ (1,2,3)

Unsorted

Endogenous antagonists/inhibitors:BAMBI
Cerberus (CER1)
Chordin
DAN (PARN)
Decorin
Follistatin
Gremlin (Drm)
LTBP1
Noggin
TGIF
Thrombospondin 1 (THBS1)
Tomoregulin 1

Antibodies:Stamulumab (against myostatin)
TRC105 (against endoglin)

Others:Endoglin

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Ascrinvacumab

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