in:Items,Shathra (Earth-001)/Items,Sisterhood of the Wasp (Earth-616)/Items,

Conceived and modeled by the elder goddessShathra ofEarth-001, the daughter ofGaea andOshtur, the Great Nest was supposed to be her attempt at a celestial map of humanity's cosmic fate. However, it was not realized as her mothers chose theGreat Web created by Shathra's little sister,Neith. Although she gave her blessing, Shathra was consumed by bitterness and wrathful envy at her sister upstaging her, so she poisoned the Great Web and laid a trap in a primal strand to summon her hence when the strand was found. Eventually,Spiderling, the Spider-Totem avatar known as thePatternmaker, examined said primal strand and unknowingly triggered the ancient trap which revived Shathra in the present day. A sting by Shathra mutated Annie into the servile "Nestling," while Shathra then soughtEnd of the Spider-Verse.^[2] As Shathra went about hunting spiders to kill or turn,^[3] she supplanted the strands of the Great Web with her molded rooms of her Great Nest, as she then sought to kill the chosen champion of the Great Web,Spider-Man 616.^[4]