Call for papers - Clinical interpretation of genome variation: volume II
Genome Medicineis calling for submissions to a new Collection on genome variation, guest edited by Dr Heidi L. Rehm and Dr Steven Harrison. Deadline 18 December 2025.
Call for papers - Genome editing in human health, disease, and therapeutics
Genome Medicine is calling for submissions to a new Collection on genome editing in human health, disease, and therapeutics, guest edited by Dr Ben Haley and Dr Francisco J. Sánchez-Rivera. Deadline 14 November 2025.
Call for papers - Vaccines
Genome Medicine is calling for submissions to a new Collection on vaccines and vaccinology, guest edited by Dr Paul Klenerman, Dr Nicholas Provine, and Dr Ramon Arens. Deadline 2 October 2025.
Call for papers - Neurogenomics: from the bench to the clinic
Genome Medicine is calling for submissions to a new Collection on the interpretation and application of genetic and genomic variation in the prevention, diagnosis, and treatment of neurological disorders, guest edited by Daniel Geschwind and Jessica Rexach. Deadline 2 September 2025.
Call for papers - Respiratory viruses: surveillance, diagnostics, and emergence
Genome Medicine is calling for submissions to a new Collection on current research on the surveillance, diagnostics, and emergence of respiratory viruses, guest edited by Jasper Fuk-Woo Chan and Vivian Huiping Shuai. Deadline 4 July 2025.
Call for papers - AI applications in cancer discovery and care
Genome Medicine is calling for submissions to a new Collection on how artificial intelligence in oncology has increased dramatically in recent years, evolving from basic algorithm development research toward incorporation into clinical application, guest edited by Dr Jakob Nikolas Kather from Dresden University of Technology and Dr Mihaela Aldea from Gustave Roussy. Deadline 10 June 2025.
Call for papers - Clinical trials resource
Genome Medicine is pleased to announce a call for papers for our Clinical Trials Resource, guest edited by Christophe Le Tourneau from the Institut Curie. We encourage work from academic-industry partnerships as well as collaboration among scientists from multi-disciplinary fields. Deadline 6 June 2025.
Call for papers - Translating the microbiome in health and disease
Genome Medicine is calling for submissions to a new Collection on translating the microbiome in health and disease guest edited by Peggy Lai. Deadline 19 May 2025.
Call for papers - Genomic research and clinical interventions for rare diseases
Genome Medicine is calling for submissions to a new Collection on genomic research and clinical advances in rare diseases, guest edited by Anna Lindstrand and Claudia Carvalho. Deadline 16 April 2025.
Call for papers - Advances in healthy aging and age-related diseases
Genome Medicine is calling for submissions to a new Collection on advances in healthy aging and
age-related diseases, guest edited by Joris Deelen and Henne Holstege. Deadline 1 April 2025.
Reviews, Research Highlights and Commentaries
Read authoritative Reviews, Opinions and other content commissioned by the Genome Medicine Editors from leading researchers:
Commentaries (including Editorials, Comments, Opinions, Q&As and Meeting reports)
Articles
STopover captures spatial colocalization and interaction in the tumor microenvironment using topological analysis in spatial transcriptomics data
Authors:Sungwoo Bae, Hyekyoung Lee, Kwon Joong Na, Dong Soo Lee, Hongyoon Choi and Young Tae Kim
Content type:Method1 April 2025DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation
Authors:Emily K.W. Lo, Adrian Idrizi, Rakel Tryggvadottir, Weiqiang Zhou, Wenpin Hou, Hongkai Ji, Patrick Cahan and Andrew P. Feinberg
Content type:Research28 March 2025Advantages of updated WHO mutation catalog combined with existing whole-genome sequencing-based approaches forMycobacterium tuberculosis resistance prediction
Authors:Yiwang Chen, Xuecong Zhang, Jialei Liang, Qi Jiang, Mijiti Peierdun, Peng Xu, Howard E. Takiff and Qian Gao
Content type:Research26 March 2025The Chinese gut virus catalogue reveals gut virome diversity and disease-related viral signatures
Authors:Qiulong Yan, Liansha Huang, Shenghui Li, Yue Zhang, Ruochun Guo, Pan Zhang, Zhixin Lei, Qingbo Lv, Fang Chen, Zhiming Li, Jinxin Meng, Jing Li, Guangyang Wang, Changming Chen, Hayan Ullah, Lin Cheng…
Content type:Research26 March 2025STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci
Authors:Laurel Hiatt, Ben Weisburd, Egor Dolzhenko, Vincent Rubinetti, Akshay K. Avvaru, Grace E. VanNoy, Nehir Edibe Kurtas, Heidi L. Rehm, Aaron R. Quinlan and Harriet Dashnow
Content type:Database26 March 2025
A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications
Authors:Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio Lönnberg
Content type:Review18 August 2017Best practices for variant calling in clinical sequencing
Authors:Daniel C. Koboldt
Content type:Review26 October 2020The Human Genome Project: big science transforms biology and medicine
Authors:Leroy Hood and Lee Rowen
Content type:Opinion13 September 2013An introduction to spatial transcriptomics for biomedical research
Authors:Cameron G. Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo and Ashraful Haque
Content type:Review27 June 2022Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Authors:Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…
Content type:Research19 April 2017
Focus: The human microbiome in health and disease
Read the latest Research and and Reviews on the human microbiome in health and disease:
Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides
Langdon, A., Schwartz, D.J., Bulow, C. et al. Genome Med 13, 28 (2021)
Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer
Hayase, E., Jenq, R.R. Genome Med 13, 107 (2021)
Strain-level epidemiology of microbial communities and the human microbiome
Yan, Y., Nguyen, L.H., Franzosa, E.A. et al. Genome Med 12, 71 (2020).
Bacteroides vulgatus and Bacteroides dorei predict immune-related adverse events in immune checkpoint blockade treatment of metastatic melanoma
Usyk, M., Pandey, A., Hayes, R.B. et al. Genome Med 13, 160 (2021).
Aims and scope
Genome Medicine publishes important advances of broad interest in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. The Journal aims to bridge the basic science and clinical research communities in areas that include, but are not limited to: cancer genomics, immuno-oncology, immunogenomics, infectious disease, microbiome, cardiology, neurogenomics, systems medicine, clinical genomics, gene therapies, precision medicine, and clinical trials. The Journal content includes original research, method, software, database and guideline articles as well as reviews, opinions and commentaries.
Article collections
Special issue
Cardiovascular disease: omics approaches and clinical applications
Guest editors: James Ware and Connie Bezzina
Special issue
New technology applications in health and disease
Guest editors: Fei Chen and Francisco De La Vega
Special issue
Advancing human genetics in underrepresented populations
Guest editors: Segun Fatumo and Krishna Aragam
Special issue
Dissecting the role of immune responses in complex brain disorders: translational and clinical insights
Guest editors: Philip de Jager and Carlos Cruchaga
Resource
Coronavirus Resource - Submit your latest research and discoveries
Guest editor: Junhua Li
Special issue
Targeting cancer evolution in the clinic
Guest editors: Razelle Kurzrock and Alberto Bardelli