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Confirmation of linkage of benign familial neonatal convulsions to D20S19 and D20S20

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Summary

Benign familial neonatal convulsions (BFNC) is an idiopathic form of epilepsy beginning within the first six months of life. Its genetic origin and autosomal dominant mode of inheritance have been suspected since its first description. Recently, the BFNC gene has been localised within chromosome 20q in one large pedigree. For the first time, we confirm here (with D20S19 and D20S20) the close linkage of BFNC to chromosome 20q in six French predigrees. In addition, the existence in these families of several cases of febrile convulsions (FC), another epileptic syndrome with an autosomal dominant genetic component, led us to study the possibility of a genetic background identical to BFNC. Our results suggest the existence of different susceptibility genes for BFNC and FC.

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Author information

Authors and Affiliations

  1. Laboratoire de Médecine Expérimentale, INSERM U.249 — CNRS UPR 41, F-34060, Montpellier, France

    Alain Malafosse, Corinne Beck & Michel Baldy-Moulinier

  2. Service de Neuropédiatrie et INSERM U.29, Hôpital Saint Vincent de Paul, F-75014, Paris, France

    Marion Leboyer, Olivier Dulac, Perrine Plouin & Pierre Grandscene

  3. INSERM U.155, F-75016, Paris, France

    Marion Leboyer, Michel Guilloud-Bataille & Josué Feingold

  4. Service d'Explorations Fonctionnelles du Système Nerveux, Hôpital de Bicêtre, F-94275, Kremlin-Bicetre, France

    Yvonne Navelet

  5. Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, F-91198, Gif sur Yvette, France

    Hassan Laklou, Daniéle Samolyk & Jacques Mallet

  6. Service de Néonatalogie, Hôpital René Dubos, F-95300, Pontoise, France

    Geneviève Mouchnino

  7. Service de Neuropédiatrie, Hôpital Calmettes, F-59000, Lille, France

    Louis Vallee

Authors
  1. Alain Malafosse
  2. Marion Leboyer
  3. Olivier Dulac
  4. Yvonne Navelet
  5. Perrine Plouin
  6. Corinne Beck
  7. Hassan Laklou
  8. Geneviève Mouchnino
  9. Pierre Grandscene
  10. Louis Vallee
  11. Michel Guilloud-Bataille
  12. Daniéle Samolyk
  13. Michel Baldy-Moulinier
  14. Josué Feingold
  15. Jacques Mallet

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