Abstract
TSH-producing pituitary adenoma is a rare cause of thyrotoxicosis, and the rarest of all types of secretory pituitary adenomas. We present a case of a 55-year-old man who, after 6 years of therapy for presumed hypothyroidism, was diagnosed with a TSH-producing pituitary adenoma. He was lost to follow-up after that, to present again with thyrotoxicosis and atrial flutter 10 years later. We review the presentation, evaluation, treatment, and differential diagnosis of TSH-producing adenomas.
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References
Beck-Peccoz P, Persani L, Mannavola D, Campi I. Pituitary tumours: TSH-secreting adenomas. Best Pract Res Clin Endocrinol Metab. 2009;23:597–606.
Rouach V, Greenman Y. Thyrotropin-secreting pituitary tumors. In: Melmed S, editor. The pituitary. Burlington: Academic Press; 2011. p. 619–36.
George JT, Thow JC, Matthews B, Pye MP, Jayagopal V. Atrial fibrillation associated with a thyroid stimulating hormone-secreting adenoma of the pituitary gland leading to a presentation of acute cardiac decompensation: a case report. J Med Case Rep. 2008;2:67.
Brucker-Davis F, Oldfield EH, Skarulis MC, Doppman JL, Weintraub BD. Thyrotropin-secreting pituitary tumors: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the national institutes of health. J Clin Endocrinol Metab. 1999;84:476–86.
Socin HV, Chanson P, Delemer B, et al. The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol. 2003;148:433–42.
Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD. Thyrotropin-secreting pituitary tumors. Endocr Rev. 1996;17:610–38.
Losa M, Mortini P, Minelli R, Giovanelli M. Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism. J Endocrinol Invest. 2006;29:555–9.
Colao A, Pivonello R, Di Somma C, Savastano S, Grasso LF, Lombardi G. Medical therapy of pituitary adenomas: effects on tumor shrinkage. Rev Endocr Metab Disord. 2009;10:111–23.
Dumitrescu AM, Refetoff S. The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta. 2013;1830(7):3987–4003.
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Authors and Affiliations
Division of Endocrinology and Metabolism, Johns Hopkins Hospital, Baltimore, MD, USA
Abdulrahman Alkabbani M.D. & Roberto Salvatori M.D.
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, 1830 E. Monument St., Suite 333, Baltimore, MD, USA
David S. Cooper M.D.
- Abdulrahman Alkabbani M.D.
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- Roberto Salvatori M.D.
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- David S. Cooper M.D.
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Correspondence toDavid S. Cooper M.D..
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Editors and Affiliations
Div. Endocrinology, Diabetes & Bone Disease, Mount Sinai School of Medicine Dept. Medicine, New York, New York, USA
Terry F. Davies
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Alkabbani, A., Salvatori, R., Cooper, D.S. (2015). TSH-Secreting Pituitary Adenoma. In: Davies, T. (eds) A Case-Based Guide to Clinical Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2059-4_6
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