• Aaron SD, Vandemheen KL, Boulet L-P, Mcivor RA, Fitzgerald JM, Hernandez P, Lemiere C, Sharma S, Field SK, Alvarez GG, Dales RE, Doucette S, Fergusson D, Canadian Respiratory Clinical Research, C (2008) Overdiagnosis of asthma in obese and nonobese adults. Can Med Assoc J 179:1121–1131

  Article  Google Scholar 

• Aaron SD, Vandemheen KL, Fitzgerald JM, Ainslie M, Gupta S, Lemière C, Field SK, Mcivor RA, Hernandez P, Mayers I, Mulpuru S, Alvarez GG, Pakhale S, Mallick R, Boulet L-P (2017) Reevaluation of diagnosis in adults with physician-diagnosed asthma. J Am Med Assoc 317:269

  Article  Google Scholar 

• Akçayir M, Akçayir G (2016) Advantages and challenges associated with augmented reality for education: a systematic review of the literature. Edu Res Rev (Elsevier) 20:1–11

  Google Scholar 

• Alberts MJ, Latchaw RE, Selman WR, Shephard T, Hadley MN, Brass LM, Koroshetz W, Marler JR, Booss J, Zorowitz RD, Croft JB, Magnis E, Mulligan D, Jagoda A, O’connor R, Cawley CM, Connors JJ, Rose-Derenzy JA, Emr M, Warren M, Walker MD (2005) Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke 36:1597–1616

  Article PubMed  Google Scholar 

• Alberts MJ, Latchaw RE, Jagoda A, Wechsler LR, Crocco T, George MG, Connolly ES, Mancini B, Prudhomme S, Gress D, Jensen ME, Bass R, Ruff R, Foell K, Armonda RA, Emr M, Warren M, Baranski J, Walker MD (2011) Revised and updated recommendations for the establishment of primary stroke centers: a summary statement from the brain attack coalition. Stroke 42:2651–2665

  Article PubMed  Google Scholar 

• Albrecht U-V, Folta-Schoofs K, Behrends M, Von Jan U (2013) Effects of Mobile augmented reality learning compared to textbook learning on medical students: randomized controlled pilot study. J Med Internet Res 15:e182

  Article PubMed PubMed Central  Google Scholar 

• Anastakis DJ, Hamstra SJ, Matsumoto ED (2000) Visual-spatial abilities in surgical training. Am J Surg 179:469–471

  Article CAS PubMed  Google Scholar 

• Atmann O, Linde K, Werner C, Dorn U, Schneider A (2019) Participation factors for asthma education programs – a cross sectional survey. BMC Pulm Med 19:256–256

  Google Scholar 

• Australian Bureau of Statistics (2017) Causes of death, Australia, 2015 [Online]. Australian Bureau of Statistics, Canberra. Available:http://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/3303.0~2015~Main%20Features~Stroke~10003. Accessed 2 May 2019

• Australian Bureau of Statistics (2018) Causes of death, Australia, 2017 [Online]. Australian Bureau of Statistics, Canberra. Available:https://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/3303.0~2017~Main%20Features~Australia’s%20leading%20causes%20of%20death,%202017~2. Accessed 6 Nov 2018

  Google Scholar 

• Australian Institute of Health and Welfare (2019) Asthma [Online]. Australian Government, Australia. Available:https://www.aihw.gov.au/reports/chronic-respiratory-conditions/asthma/contents/asthma. Accessed 2020

• Bacca J, Baldiris S, Fabregat R, Graf S, Kinshuk (2014) Augmented reality trend in education: a systematic review of research and application. J Edu Soc 17:133–149

  Google Scholar 

• Barmaki R, Yu K, Pearlman R, Shingles R, Bork F, Osgood GM, Navab N (2019) Enhancement of anatomical education using augmented reality: an empirical study of body painting. Anat Sci Educ 12:599–609

  Article PubMed  Google Scholar 

• Birt JR, Stromberga Z, Cowling MA, Moro C (2018) Mobile mixed reality for experiential learning and simulation in medical and health sciences education. Information (Switzerland) 9:31

  Google Scholar 

• British Computer Society (2014) Augmented reality learning [Online]. British Computer Society, Britain. Available:https://www.bcs.org/content-hub/augmented-reality-learning. Accessed 14 Nov 2019

• Brun H, Bugge RAB, Suther LKR, Birkeland S, Kumar R, Pelanis E, Elle OJ (2019) Mixed reality holograms for heart surgery planning: first user experience in congenital heart disease. Eur Heart J Cardiovasc Imaging 20:883–888

  Article CAS PubMed  Google Scholar 

• Buckner EB, Copeland DJ, Miller KS, Holt TO (2018) School-based interprofessional asthma self-management education program for middle school students: a feasibility trial. Prog Community Health Partnersh 12:45–59

  Article PubMed  Google Scholar 

• Candelise L, Gattinoni M, Bersano A, Micieli G, Sterzi R, Morabito A (2007) Stroke-unit care for acute stroke patients: an observational follow-up study. Lancet 369:299–305

  Article PubMed  Google Scholar 

• Canonica G, Baena-Cagnani CE, Blaiss MS, Dahl R, Kaliner MA, Valovirta E (2007) Unmet needs in asthma: Global asthma physician and patient (GAPP) survey: global adult findings. Allergy 62:668–674

  Article CAS PubMed  Google Scholar 

• Carpenter DM, Estrada RD, Roberts CA, Elio A, Prendergast M, Durbin K, Jones GC, North S (2017) Urban-rural differences in school nurses’ asthma training needs and access to asthma resources. J Pediatr Nurs 36:157–162

  Article PubMed PubMed Central  Google Scholar 

• Chang Y, Ho H, Pan C, Sung Y, Kuo-En C (2015) Apply an augmented reality in a mobile guidance to increase sense of place for heritage places. J Edu Technol Soc 18:166–178

  Google Scholar 

• Codd AM, Choudhury B (2011) Virtual reality anatomy: is it comparable with traditional methods in the teaching of human forearm musculoskeletal anatomy? Anat Sci Educ 4:119

  Article PubMed  Google Scholar 

• Coelho ACC, Cardoso LSB, De Souza-Machado C, Souza-Machado A (2016) The impacts of educational asthma interventions in schools: a systematic review of the literature. Can Respir J 2016:8476206–8476206

  Google Scholar 

• Densen P (2011) Challenges and opportunities facing medical education. Trans Am Clin Climatol Assoc 122:48–58

  PubMed PubMed Central  Google Scholar 

• DI Carlo A, Lamassa M, Wellwood I, Bovis F, Baldereschi M, Nencini P, Poggesi A, Cramaro A, Pescini F, Lucente G, Wolfe CD, Inzitari D (2011) Stroke unit care in clinical practice: an observational study in the Florence center of the European Registers of Stroke (EROS) Project. Eur J Neurol 18:686–694

  Article PubMed  Google Scholar 

• Divecha CA, Tullu MS, Jadhav DU (2020) Parental knowledge and attitudes regarding asthma in their children: impact of an educational intervention in an Indian population. Pediatr Pulmonol 9:34

  Google Scholar 

• Drummond K, Houston T, Irvine T (2014) The rise and fall and rise of virtual reality. Vox Media, Washington

  Google Scholar 

• Ekstrand C, Jamal A, Nguyen R, Kudryk A, Mann J, Mendez I (2018) Immersive and interactive virtual reality to improve learning and retention of neuroanatomy in medical students: a randomized controlled study. CMAJ Open 6:E103–E109

  Article PubMed PubMed Central  Google Scholar 

• Erolin C (2019) Interactive 3D digital models for anatomy and medical education. Adv Exp Med Biol 1138:1–16

  Article PubMed  Google Scholar 

• Ferrer-Torregrosa J, Torralba-Estelles J, Rodríguez MÁ, García S, Barcia J (2015) ARBOOK: development and assessment of a tool based on augmented reality for anatomy. J Sci Educ Technol 24:119–124

  Article  Google Scholar 

• Global Asthma Network (2018) The global asthma report 2018 [Online]. Auckland, New Zealand. Available:http://www.globalasthmareport.org/. Accessed 2020

• Govan L, Langhorne P, Dennis M, Hankey G, Weir C, Williams B, Asplund K, Berman P, Blomstrand C, Britton M, Cabral N, Cavallini A, Dey P, Hamrin E, Hankey G, Indredavik B, Kalra L, Kaste M, Laursen S (2007) Organised Inpatient (Stroke Unit) Care for Stroke (Cochrane review). Cochrane Database Syst Rev (Online) 4:CD000197

  Google Scholar 

• Gunn T, Jones L, Bridge P, Rowntree P, Nissen L (2018) The use of virtual reality simulation to improve technical skill in the undergraduate medical imaging student. Interact Learn Environ 26:613–620

  Article  Google Scholar 

• Hackett M, Proctor M (2018) The effect of autostereoscopic holograms on anatomical knowledge: a randomised trial. Med Educ 52:1147–1155

  Article PubMed  Google Scholar 

• Hegarty M, Keehner M, Khooshabeh P, Montello DR (2009) How spatial abilities enhance, and are enhanced by, dental education. Learn Individ Differ 19:61–70

  Article  Google Scholar 

• Heilig ML (1962) Sensorama simulator. Google Patents

  Google Scholar 

• Hoffman MA (2016) Microsoft Hololens development edition. Science 353:876–876

  Article CAS  Google Scholar 

• Howarth PA, Costello PJ (1997) The occurrence of virtual simulation sickness symptoms when an HMD was used as a personal viewing system. Displays 18:107–116

  Article  Google Scholar 

• Huber T, Wunderling T, Paschold M, Lang H, Kneist W, Hansen C (2018) Highly immersive virtual reality laparoscopy simulation: development and future aspects. Int J Comput Assist Radiol Surg 13:281–290

  Article PubMed  Google Scholar 

• Incekara F, Smits M, Dirven C, Vincent A (2018) Clinical feasibility of a wearable mixed-reality device in neurosurgery. World Neurosurg 118:422–427

  Article  Google Scholar 

• Johnson JD, Theurer WM (2014) A stepwise approach to the interpretation of pulmonary function tests. Am Fam Physician 89:359–366

  PubMed  Google Scholar 

• Kim S-J, Shin H, Lee J, Kang S, Bartlett R (2017) A smartphone application to educate undergraduate nursing students about providing care for infant airway obstruction. Nurse Educ Today 48:145–152

  Article PubMed  Google Scholar 

• Kuehn BM (2018) Virtual and augmented reality put a twist on medical education. JAMA 319:756–758

  Article PubMed  Google Scholar 

• Langhorne P, O’donnell MJ, Chin SL, Zhang H, Xavier D, Avezum A, Mathur N, Turner M, Macleod MJ, Lopez-Jaramillo P, Damasceno A, Hankey GJ, Dans AL, Elsayed A, Mondo C, Wasay M, Czlonkowska A, Weimar C, Yusufali AH, Hussain FA, Lisheng L, Diener HC, Ryglewicz D, Pogosova N, Iqbal R, Diaz R, Yusoff K, Oguz A, Wang X, Penaherrera E, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Magazi D, Nilanont Y, Rosengren A, Oveisgharan S, Yusuf S (2018) Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study. Lancet 391:2019–2027

  Article PubMed  Google Scholar 

• Logishetty K, Rudran B, Gofton W, Beaule P, Cobb JP (2019) Total hip arthroplasty training in virtual reality transfers to the real world: a randomized blinded study. Orthop Proc 101-B:27

  Google Scholar 

• Looijmans-van den Akker I, van Luijn K, Verheij T (2016) Overdiagnosis of asthma in children in primary care: a retrospective analysis. Br J Gen Pract 66:e152–e157

  Article PubMed PubMed Central  Google Scholar 

• Lu S, Liu Y (2015) Integrating augmented reality technology to enhance children’s learning in marine education. J Environ Edu Res 21:1–17

  Google Scholar 

• Lucas C, Aly S, Touboul C, Sellami R, Guillaume X, Garcia G (2020) Patient-reported outcome in two chronic diseases: A comparison of quality of life and response profiles in severe migraine and severe asthma. Patient Relat Outcome Meas 11:27–37

  Article PubMed PubMed Central  Google Scholar 

• Lufler RS, Zumwalt AC, Romney CA, Hoagland TM (2012) Effect of visual–spatial ability on medical students’ performance in a gross anatomy course. Anat Sci Educ 5:3–9

  Article PubMed  Google Scholar 

• Mahmood T, Scaffidi MA, Khan R, Grover SC (2018) Virtual reality simulation in endoscopy training: current evidence and future directions. World J Gastroenterol 24:5439–5445

  Article PubMed PubMed Central  Google Scholar 

• Maniam P, Schnell P, Dan L, Portelli R, Erolin C, Mountain R, Wilkinson T (2020) Exploration of temporal bone anatomy using mixed reality (HoloLens): development of a mixed reality anatomy teaching resource prototype. J Vis Commun Med 43:17–26

  Article PubMed  Google Scholar 

• Mayer (2014) The Cambridge handbook of multimedia learning. Cambridge University Press, Cambridge

  Book  Google Scholar 

• Mcgrath JL, Taekman JM, Dev P, Danforth DR, Mohan D, Kman N, Crichlow A, Bond WF (2018) Using virtual reality simulation environments to assess competence for emergency medicine learners. Acad Emerg Med 25:186–195

  Article PubMed  Google Scholar 

• Medical Deans (2019) Student statistics report: 2018-2019. In: Deans M (ed) Student statistics reports, Australia and New Zealand

  Google Scholar 

• Meretoja A, Roine RO, Kaste M, Linna M, Roine S, Juntunen M, Erila T, Hillbom M, Marttila R, Rissanen A, Sivenius J, Hakkinen U (2010) Effectiveness of primary and comprehensive stroke centers: PERFECT stroke: a nationwide observational study from Finland. Stroke 41:1102–1107

  Article PubMed  Google Scholar 

• Middleton S, Mcelduff P, Ward J, Grimshaw JM, Dale S, D’este C, Drury P, Griffiths R, Cheung NW, Quinn C, Evans M, Cadilhac D, Levi C (2011) Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC): a cluster randomised controlled trial. Lancet 378:1699–1706

  Article PubMed  Google Scholar 

• Mitsuno D, Ueda K, Hirota Y, Ogino M (2019) Effective application of mixed reality device HoloLens: simple manual alignment of surgical field and holograms. Plast Reconstr Surg 143:647–651

  Article CAS PubMed  Google Scholar 

• Moro C, Chess-Williams R (2012) Non-adrenergic, non-cholinergic, non-purinergic contractions of the urothelium/lamina propria of the pig bladder. Auton Autacoid Pharmacol 32:53–59

  Article CAS PubMed  Google Scholar 

• Moro C, Gregory S (2019) Utilising anatomical and physiological visualisations to enhance the face-to-face student learning experience in biomedical sciences and medicine. Adv Exp Med Biol 1156:41–48

  Article PubMed  Google Scholar 

• Moro C, Mclean M (2017) Supporting students’ transition to university and problem-based learning. Med Sci Educ 27:353–361

  Article  Google Scholar 

• Moro C, Edwards L, Chess-Williams R (2016a) 5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria. Int J Urol 23:946–951

  Article CAS PubMed  Google Scholar 

• Moro C, Stromberga Z, Raikos A, Stirling A (2016b) Combining virtual (Oculus Rift & Gear VR) and augmented reality with interactive applications to enhance tertiary medical and biomedical curricula. In: SIGGRAPH ASIA 2016 Symposium on education: talks. Association for Computing Machinery, Macau

  Google Scholar 

• Moro C, Stromberga Z, Raikos A, Stirling A (2017a) The effectiveness of virtual and augmented reality in health sciences and medical anatomy. Anat Sci Educ 10:549–559

  Google Scholar 

• Moro C, Stromberga Z, Stirling A (2017b) Virtualisation devices for student learning: comparison between desktop-based (Oculus Rift) and mobile-based (Gear VR) virtual reality in medical and health science education. Australas J Educ Technol 33:1–10

  Article  Google Scholar 

• Moro C, Štromberga Z, Raikos A, Stirling A (2017c) The effectiveness of virtual and augmented reality in health sciences and medical anatomy. Anat Sci Educ 10:549–559

  Article PubMed  Google Scholar 

• Morris MJ, Pearson DJ (2019) Asthma epidemiology [Online]. Available:https://emedicine.medscape.com/article/296301-overview#a6. Accessed 2020

• Moro C, Smith J, Stromberga Z (2019a) Multimodal learning in health sciences and medicine: merging technologies to enhance student learning and communication. In: Rea PM (ed) Biomedical visualisation: volume 5. Springer International Publishing, Cham

  Google Scholar 

• Moro C, Spooner A, Mclean M (2019b) How prepared are students for the various transitions in their medical studies? An Australian university pilot study. MedEdPublish 8:1–14

  Google Scholar 

• Moro C, Stromberga Z, Birt JR (2020a) Technology considerations in health professions and clinical education. In: Nestel D, Reedy G, Mckenna L, Gough S (eds) Clinical education for the health professions: theory and practice. Springer, Singapore

  Google Scholar 

• Moro C, Phelps C, Stromberga Z (2020b) Utilizing serious games for physiology and anatomy learning and revision. Adv Physiol Educ 44(3):505–507

  Google Scholar 

• Moro C, Birt J, Stromberga Z, Phelps C, Clark J, Glasziou P, Scott AM (2021a) Virtual and augmented reality enhancements to medical and science student physiology and anatomy test performance: a systematic review and meta-analysis. Anat Sci Educ. In press.https://doi.org/10.1002/ase.2049

• Moro C, Phelps C, Redmond P, Stromberga Z (2021b) HoloLens and mobile augmented reality in medical and health science education: a randomised controlled trial. Br J Educ Technol: e13049.https://doi.org/10.1111/bjet.13049

• Pamuk E, Mukuc D, Heck K, Reuben C, Lochner K (1998) Socioeconomic status and health Chartbook. Health. National Center for Health Statistics, Hyattsville

  Google Scholar 

• Panaretos C, Colthorpe K, Kibedi J, Ainscough L (2019) Biomedical science students’ intended graduate destinations. Int J Innov Sci Math Educ 27:1–16

  Article  Google Scholar 

• Papi A, Brightling C, Pedersen SE, Reddel HK (2018) Asthma. Lancet 391:783–800

  Article PubMed  Google Scholar 

• Pratt P, Ives M, Lawton G, Simmons J, Radev N, Spyropoulou L, Amiras D (2018) Through the HoloLens™ looking glass: augmented reality for extremity reconstruction surgery using 3D vascular models with perforating vessels. Eur Radiol Exp 2:2–2

  Article PubMed PubMed Central  Google Scholar 

• Pulijala Y, Ma M, Pears M, Peebles D, Ayoub A (2018) Effectiveness of immersive virtual reality in surgical training—A randomized control trial. J Oral Maxillofac Surg 76:1065–1072

  Article PubMed  Google Scholar 

• Reznik M, Greenberg E, Cain A, Halterman JS, Ivanna Avalos M (2019) Improving teacher comfort and self-efficacy in asthma management. J Asthma 57:1–7

  Google Scholar 

• Richards P (2003) Learning medicine an informal guide to a career in medicine. BMJ, London

  Google Scholar 

• Rosenbaum E, Klopfer E, Perry J (2007) On location learning: authentic applied science with networked augmented realities. J Sci Educ Technol 16:31–45

  Article  Google Scholar 

• Schulz GB, Grimm T, Buchner A, Jokisch F, Casuscelli J, Kretschmer A, Mumm J-N, Ziegelmüller B, Stief CG, Karl A (2019) Validation of a high-end virtual reality simulator for training transurethral resection of bladder tumors. J Surg Educ 76:568–577

  Article PubMed  Google Scholar 

• Silva RDC, Albuquerque SGC, Muniz AV, Filho PPR, Ribeiro S, Pinheiro PR, Albuquerque VHC (2017) Reducing the schizophrenia stigma: A new approach based on augmented reality. Comput Intell Neurosci 2017:2721846

  Article PubMed PubMed Central  Google Scholar 

• Soo YY, Saini B, Moles RJ (2013) Can asthma education improve the treatment of acute asthma exacerbation in young children? J Paediatr Child Health 49:353–360

  Article PubMed  Google Scholar 

• Stegers-Jager KM, Cohen-Schotanus J, Themmen APN (2017) The four-tier continuum of academic and behavioral support (4T-CABS) model: an integrated model for medical student success. Acad Med 92:1525

  Article PubMed  Google Scholar 

• Stenhouse (1975) An introduction to curriculum research and development. Heinemann, Oxford

  Google Scholar 

• Stromberga Z, Chess-Williams R, Moro C (2019) Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors. Sci Rep 9:3899

  Article PubMed PubMed Central CAS  Google Scholar 

• Stromberga Z, Chess-Williams R, Moro C (2020) Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues. Sci Rep 10:4116

  Article CAS PubMed PubMed Central  Google Scholar 

• Su W, Xiao Y, He S, Huang P, Deng X (2018) Three-dimensional printing models in congenital heart disease education for medical students: a controlled comparative study. BMC Med Educ 18:178

  Article PubMed PubMed Central  Google Scholar 

• Turney BW (2007) Anatomy in a modern medical curriculum. Ann R Coll Surg Engl 89:104–107

  Article CAS PubMed PubMed Central  Google Scholar 

• Tyrrel PRA, Cullen K, Richards A, Swain S, Turner C, Wonderling D, Bowmaster A, Day D, Ford G, Hatton S, Korner J, Mcmanus R, Molyneux A, Potter J, Allison R, Barker J, Kirkpatrick P, Lamont P, Morse M, Rothwell P, Baldwin N, Willis S (2008) Stroke: National Clinical Guideline for Diagnosis and Initial management of acute stroke and Transient Ischaemic Attack (TIA). National Institute for Health and Clinical Excellence, London

  Google Scholar 

• Vijn TW, Fluit CRMG, Kremer JAM, Beune T, Faber MJ, Wollersheim H (2017) Involving medical students in providing patient education for real patients: A scoping review. J Gen Intern Med 32:1031–1043

  Article PubMed PubMed Central  Google Scholar 

• Vince J (1995) Virtual reality systems. Addison-Wesley, New York

  Google Scholar 

• Wang C, Daniel BK, Asil M, Khwaounjoo P, Cakmak YO (2020) A randomised control trial and comparative analysis of multi-dimensional learning tools in anatomy. Sci Rep 10:6120

  Article CAS PubMed PubMed Central  Google Scholar 

• World Health Organisation (2019) Asthma global prevalence [Online]. Available:https://www.who.int/news-room/q-a-detail/asthma. Accessed 2020

• Wu AC, Greenberger PA (2018) Asthma: overdiagnosed, underdiagnosed, and ineffectively treated. J Allergy Clin Immunol Pract 6:801–802

  Article PubMed PubMed Central  Google Scholar 

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