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IGF-1

링크 편집

위키백과, 우리 모두의 백과사전.

IGF1

사용 가능한 구조

PDB

동원체 검색:PDBe RCSB

PDB ID 코드 목록
1B9G,1GZR,1GZY,1GZZ,1H02,1H59,1IMX,1PMX,1TGR,1WQJ,2DSR,2GF1,3GF1,3LRI,1BQT,4XSS

식별자

다른 이름

IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF

외부 ID

OMIM:147440 MGI:96432 HomoloGene:515 GeneCards:IGF1

유전자 위치 (인간)

염색체	12번 염색체^[1]

자리	12q23.2	시작	102,395,874bp^[1]
자리	12q23.2	끝	102,481,744bp^[1]

유전자 위치 (쥐)

염색체	10번 염색체 (쥐)^[2]

자리	10 C1\|10 43.7 cM	시작	87,694,127bp^[2]
자리	10 C1\|10 43.7 cM	끝	87,772,904bp^[2]

RNA 발현 패턴

Bgee

인간

쥐(동원체)

최상위 발현

심장막

tail of epididymis

tendon of biceps brachii

gastric mucosa

superficial temporal artery

정낭

요도

caput epididymis

부고환몸통

자궁속막

최상위 발현

stria vascularis

속목동맥

efferent ductule

외경동맥

홍채

left lobe of liver

쓸개

stroma of bone marrow

genital tubercle

백색지방조직

추가 참조 발현 데이터

BioGPS


추가 참조 발현 데이터

유전자 온톨로지
분자 함수	hormone activity insulin receptor binding growth factor activity integrin binding 단백질 결합 insulin-like growth factor receptor binding
세포 성분	세포밖공간 exocytic vesicle insulin-like growth factor binding protein complex platelet alpha granule lumen insulin-like growth factor ternary complex alphav-beta3 integrin-IGF-1-IGF1R complex 세포막 세포 바깥쪽
생물학적 과정	positive regulation of transcription regulatory region DNA binding skeletal system development positive regulation of glucose import muscle organ development positive regulation of Ras protein signal transduction response to heat positive regulation of cardiac muscle hypertrophy positive regulation of smooth muscle cell migration DNA 복제 positive regulation of insulin-like growth factor receptor signaling pathway phosphatidylinositol 3-kinase signaling positive regulation of DNA binding Ras protein signal transduction 세포 증식 positive regulation of mitotic nuclear division positive regulation of trophectodermal cell proliferation positive regulation of glycogen biosynthetic process positive regulation of fibroblast proliferation ERK1 and ERK2 cascade negative regulation of extrinsic apoptotic signaling pathway cell activation negative regulation of oocyte development positive regulation of transcription, DNA-templated bone mineralization involved in bone maturation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of MAPK cascade proteoglycan biosynthetic process positive regulation of activated T cell proliferation positive regulation of epithelial cell proliferation negative regulation of release of cytochrome c from mitochondria protein stabilization myotube cell development positive regulation of DNA replication myoblast proliferation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration positive regulation of protein secretion positive regulation of glycoprotein biosynthetic process 유전자 발현의 조절 phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation 근비대 protein kinase B signaling regulation of multicellular organism growth positive regulation of cell migration platelet degranulation positive regulation of calcineurin-NFAT signaling cascade positive regulation of phosphatidylinositol 3-kinase signaling myoblast differentiation glycolate metabolic process positive regulation of glycolytic process negative regulation of smooth muscle cell apoptotic process 신호전달 positive regulation of transcription by RNA polymerase II positive regulation of cell growth involved in cardiac muscle cell development positive regulation of cell population proliferation 조골세포 분화의 상향조절 activation of protein kinase B activity insulin-like growth factor receptor signaling pathway 세포자멸사 과정의 하향조절 positive regulation of tyrosine phosphorylation of STAT protein 신호전달 수용체 활성의 조절 positive regulation of gene expression negative regulation of gene expression cellular response to amyloid-beta positive regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production negative regulation of neuroinflammatory response negative regulation of amyloid-beta formation
출처:Amigo /QuickGO

동원체

종

인간

쥐

앙트레


3479


16000

앙상블


ENSG00000017427


ENSMUSG00000020053

유니프롯


P05019


P05017

RefSeq (mRNA)


NM_000618 NM_001111283 NM_001111284 NM_001111285

NM_001111274 NM_001111275 NM_001111276 NM_010512 NM_184052
NM_001314010

RefSeq(단백질)


NP_000609 NP_001104753 NP_001104754 NP_001104755


NP_001104744 NP_001104745 NP_001104746 NP_001300939 NP_034642

위치(UCSC)

Chr 12: 102.4 – 102.48 Mb

Chr 10: 87.69 – 87.77 Mb

PubMed 검색

^[3]

^[4]

위키데이터

인간 보기/편집

쥐 보기/편집

소마토메딘 C(somatomedin C)라고도 불리는인슐린유사 성장인자 1(Insulin like growth factor 1,IGF-1)은 어린 시절의 성장기 발달에 세포증식의 촉진과 관련해서 중요한 역할을 하는인슐린과 분자 구조가 유사한호르몬이며 성인에게는신진 대사에 효과가 있다고 알려진 물질이다.

그러나 과학자들은 이러한 사실로 인해서 신체의 세포증식및 사멸의 사이클이 깨질수있는 불균형을 염려한다. 즉 세포증식의 효과가 신체가 불필요로하는 사멸주기에 들어간 대상 세포에까지 영향을 주어 안좋은 세포를 계속 증식시킴으로써 면역력에 악영향을 줄 수 있다는 견해를 언급하고있다.

같이 보기

[편집]

유제품알레르기

각주

[편집]

↑^가^나^다GRCh38: Ensembl release 89: ENSG00000017427 -앙상블, May 2017
↑^가^나^다GRCm38: Ensembl release 89: ENSMUSG00000020053 -앙상블, May 2017
↑“Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.
↑“Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.

EBS 하나뿐인지구-우유,소젖을먹는다는것에대하여
(대한암협회가 권고하는 암 예방 수칙 14) www.gyeyang.go.kr › main › bbs › bbsMsgFileDown
월간조선-[抗癌식탁 프로젝트 된장·김치가 항암식품이라고?엉터리 항암식품 정보가 건강을 망친다]

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