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Research Article
Hiss and tell: What influences venom yields of India’s big four snakes?
Snake venoms have evolved over millions of years to subdue prey and deter predators rapidly. The potency and amount of venom differ both within and across species, and are primarily influenced by their ecology and environment. Understanding venom yields in clinically relevant species is essential for refining treatment approaches for snakebite. Despite this, venom yields have seldom been documented...
Image credit: Chandan Singh, Flickr
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Current IssueOctober 2025
11/03/2025
Research Article
Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land
Illegal mining expanded in the Brazilian Amazon since 2018, leading to increases in malaria among indigenous populations, particularly the Yanomami. We describe the temporal and spatial pattern of malaria and mining in indigenous lands and quantify the impact of mining on malaria among the Yanomami. We estimate that a 1% increase in the annual mining area was associated with a 24% (95% CrI: 17%, 32%) increase in...
Image credit: pntd.0013677
10/31/2025
Review
Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids
Trypanosomatid parasites and the diseases they cause affect more than 30 million people annually worldwide. To develop treatments for these diseases, it is critical to understand how trypanosomatid biology protects the parasite, so that these mechanisms may be exploited as drug targets. An important aspect of trypanosomatid survival is protection from oxidative damage inflicted by the host. Reactive oxygen...
Image credit: pntd.0013626
11/03/2025
Research Article
Virome profiling ofCulex tarsalis through small RNA-seq: A challenge of suboptimal samples
Viral infections in mosquitoes trigger the RNA interference (RNAi) pathway, a key antiviral defense mechanism that generates virus-derived small RNAs (vsRNAs). Given the natural enrichment of vsRNAs during infection and their stability, small RNA sequencing (sRNA-seq) has emerged as a powerful tool for virome characterization.Culex tarsalis is a...
Image credit: James Gathany, USCDCP
10/29/2025
Viewpoints
Harnessing traditional healers role in strengthening Africa’s public health response: A case study of Mpox outbreak
Mpox, a zoonotic viral disease endemic in Central and West Africa, has posed major public health challenges, particularly following the 2022 outbreak. The World Health Organization declared it a public health emergency of international concern...
Image credit: NIAID
10/30/2025
Research Article
Hidden threats in urban environments:Angiostrongylus cantonensis in Banda Aceh’s cityscape
Angiostrongylus cantonensis is a mollusk-borne parasitic nematode originating in Southeast Asia. Commonly known as the rat lungworm, it uses rats as definitive hosts, though other mammals, including humans, can be infected and typically suffer from neurological disorders. This study focuses on the parasite’s...
Image credit: pntd.0013634
10/31/2025
Research Article
Engineered Nanobodies for early and accurate diagnosis of dengue virus infection
Pavan and colleagues
Image credit: pntd.0013168
11/04/2025
Research Article
Crimean-Congo hemorrhagic fever virus NSm protein inhibits the type I interferon signaling by binding to STAT2
Yoshikawa and colleagues
Image credit: pntd.0013695
11/05/2025
Research Article
Evaluation of a One Health public health program based on minimum inputs to controlTaenia solium in Madagascar
Andria-Mananjara and colleagues
Image credit: pntd.0013624
10/31/2025
Research Article
Assessment of vector control strategies based on massAedes (Stegomyia) mosquito trapping (AGOs traps) pilot study in a US-Mexico border region of South Texas
Aguilar-Durán, Ramírez and colleagues
Image credit: pntd.0013665
Vector-borne pathogen surveillance in a metagenomic world
Progress interrogating TRPMPZQ as the target of praziquantel
The use of artificial intelligence to improve mycetoma management
A lesion in two: Buruli ulcer and squamous cell carcinoma coexistence
Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology