CD30 , conosciuto anche comeTNFRSF8 , è unaproteina dimembrana cellulare appartenente alla famiglia dei recettori per i fattori di necrosi tumorale emarker tumorali .
Pattern di espressione del gene TNFRSF8 Questo recettore è espresso mediante attivazione, dalle cellule T e B. TRAF2 e TRAF5 possono interagire con questo recettore, e mediare la trasduzione del segnale che porta all'attivazione di NF-κB. Si tratta di un regolatore che promuove l'apoptosi , ed è in grado di limitare il potenziale proliferativo delle cellule CD8 T e quindi proteggere il corpo contro l'autoimmunità . Due varianti di trascrizione tramitesplicing alternativo di questo gene che codificano dueisoforme della proteina.[ 1]
CD30 è associato al linfoma anaplastico a grandi cellule. Viene espresso nel carcinoma embrionale, ma non nelseminoma ed è quindi un indicatore utile per distinguere tra questi tumori delle cellule germinali.[ 2] [ 3]
CD30 effettua interazioni proteina-proteina con:TRAF5 ,[ 4] TRAF1 ,[ 5] TRAF2 .[ 4] [ 5] TRAF3 .[ 5]
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