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http://hdl.handle.net/2433/126715このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.imlet.2010.04.003.pdf | 1.28 MB | Adobe PDF | 見る/開く |
| タイトル: | Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells. |
| 著者: | Chen, Zhe Yoshihara, Eiji Son, Aoi Matsuo, Yoshiyuki Masutani, Hiroshi  Sugie, Katsuji Maeda, Michiyuki Yodoi, Junji |
| 著者名の別形: | 淀井, 淳司 |
| キーワード: | Human T cell leukemia virus type 1 Adult T cell leukemia Glucocorticoid Annexin A1 Thioredoxin binding protein-2/thioredoxin interacting protein Apoptosis |
| 発行日: | 15-Jun-2010 |
| 出版者: | Elsevier B.V. |
| 誌名: | Immunology letters |
| 巻: | 131 |
| 号: | 1 |
| 開始ページ: | 11 |
| 終了ページ: | 18 |
| 抄録: | Glucocorticoid (GC) is widely used for therapeutic purposes in immunological and hematological disorders. Annexin A1 (ANXA1/lipocortin-1/lipomodulin), a GC-inducible molecule, was regarded as a vital anti-inflammatory mediator of GC. Thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP), a regulator of redox reactions, cell growth and lipid metabolism, was also reportedly induced by GC. HTLV-I infected T cells undergo the transition from the IL-2 dependent to IL-2 independent growth during the long-term culture in vitro. We found that these T cells responded to GC with growth arrest and apoptosis in the IL-2 dependent growth stage, whereas they failed to respond to GC after their growth had shifted into the IL-2 independent stage. Here we employed these T cell lines and studied the roles of ANXA1 and TBP-2 in mediating GC-induced apoptosis. In GC-sensitive T cells, ANXA1 expression was negligible and unaffected by GC treatment, whereas TBP-2 was expressed and induced by GC treatment. In GC-resistant T cells, however, ANXA1 was highly expressed regardless of GC treatment and promoted cellular proliferation. In contrast, TBP-2 expression was lost and could not mediate the GC-induced apoptosis. In conclusion, these results suggest that TBP-2, but not ANXA1, is directly involved in the switching of GC sensitivity and GC resistance in HTLV-I infected T cell lines, whereas ANXA1 may be a biomarker indicative of the advanced stage of the transformation. |
| 著作権等: | © 2010 Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/126715 |
| DOI(出版社版): | 10.1016/j.imlet.2010.04.003 |
| PubMed ID: | 20398702 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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