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Adult T cell Leukemia-Lymphoma
http://hdl.handle.net/10069/28943
http://hdl.handle.net/10069/2894384d965cf-ef8e-41ac-97fd-260b9b992e75
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
 Hema17_S32.pdf (180.9 kB) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-08-06 | |||||||
| タイトル | ||||||||
| タイトル | Adult T cell Leukemia-Lymphoma | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | ATL | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | HTLV-1 | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Molecular pathophysiology | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Prevention and treatment | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 | Tsukasaki, Kunihiro× Tsukasaki, Kunihiro
| |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Adult T-cell leukemialymphoma (ATL) was first described in 1977 as a distinct clinico-pathological entity with a suspected viral etiology. Subsequently, a novel RNA retrovirus, human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) was isolated from a cell line established from the leukemic cells of an ATL patient, and the finding of a clear association with ATL led to its inclusion among human carcinogenic pathogens. The three major routes of HTLV-1 transmission are mother-to-child infections via breast milk, sexual intercourse, and blood transfusions. HTLV-1 infection early in life, presumably from breast feeding, is crucial in the development of ATL. The diversity in clinical features and prognosis of patients with this disease has led to its subtype-classification into four categories, acute, lymphoma, chronic, and smoldering types defined by organ involvement, and LDH and calcium values. In cases of acute, lymphoma, or unfavorable chronic subtypes (aggressive ATL), intensive chemotherapy such as VCAP-AMP-VECP is usually recommended. In cases of favorable chronic or smoldering ATL (indolent ATL), watchful waiting until disease progression has been recommended although the long term prognosis was inferior to those of, for instance, chronic lymphoid leukemia. Retrospective analysis suggested that the combination of interferon alpha and zidovudine was apparently promising for the treatment of ATL, especially for types with leukemic manifestation. Allogeneic hematopoietic stem cell transplantation is also promising for the treatment of aggressive ATL possibly reflecting graft vs. ATL effect. Several new agent-trials for ATL are ongoing and in preparation, including a defucosylated humanized anti-CC chemokine receptor 4 monoclonal antibody. Two steps should be considered for the prevention of HTLV-1-associated ATL. The first is the prevention of HTLV-1 infections and the second is the prevention of ATL among HTLV-1 carriers. So far, no agent has been found to be effective for the latter. Further investigation on the pathogenesis of ATL is crucial for the prevention and treatment of this refractory leukemialymphoma. | |||||||
| 書誌情報 | Hematology 巻 17, 号 SUPPL.1, p. S32-S35, 発行日 2012-04-01 | |||||||
| 出版者 | ||||||||
| 出版者 | W. S. Maney & Son Ltd | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 10245332 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1179/102453312X13336169155330 | |||||||
| 権利 | ||||||||
| 権利情報 | © W. S. Maney & Son Ltd 2012. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Hematology, 17(SUPPL.1), pp.S32-S35; 2012 | |||||||
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