Pathophysiology, aetiology and treatment of gastroparesis
File(s)gastroparesis accepted version.docx (771.1 KB)
Accepted version
Author(s)
Sullivan, Andrew
Temperley, Laura
Ruban, Aruchuna
Type
Journal Article
Abstract
Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenced by various inputs including the central nervous system, enteric nervous system and gut hormones. Developments in our understanding of gastroparesis have now demonstrated dysfunction in these systems, thus disrupting normal gastric emptying. Once mechanical obstruction is excluded, gastric scintigraphy remains the gold standard for diagnosis although wireless motility capsule and breath testing are alternative methods for diagnosis. Treatment for gastroparesis is challenging, and widely available therapies are often limited either by their poor evidence for efficacy or concerns over their long-term safety profile. Novel prokinetic agents have shown initial promise in clinical trials, and new endoscopic techniques such as gastric per-oral endoscopic myotomy are emerging. These new treatment modalities may provide an option in refractory gastroparesis with the adage of reduced morbidity compared to surgical treatments.
Date Issued
2020-06-01
Date Acceptance
2020-04-17
Citation
Digestive Diseases and Sciences, 2020, 65 (6), pp.1615-1631
ISSN
0163-2116
Publisher
Springer (part of Springer Nature)
Start Page
1615
End Page
1631
Journal / Book Title
Digestive Diseases and Sciences
Volume
65
Issue
6
Copyright Statement
© 2020 Springer Science+Business Media, LLC, part of Springer Nature. The final publication is available at Springer via https://doi.org/10.1007/s10620-020-06287-2
Subjects
1103 Clinical Sciences
Gastroenterology & Hepatology
Publication Status
Published
Date Publish Online
2020-04-30