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TaxNorm is the R package for a novel feature-wise normalization method for microbiome data based on zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth to better capture the microbiome data nature.

Current stable release:

install.packages("TaxaNorm")

Build from GitHub:

if (!require(remotes)) install.packages("remotes")remotes::install_github("wangziyue57/TaxaNorm",dependencies=TRUE,build_vignettes=TRUE)

Please cite our original paper: Wang Z, Lloyd D, Zhao S, Motsinger-Reif A. Taxanorm: a novel taxa-specific normalization approach for microbiome data. BMC bioinformatics. 2024 Sep 16;25(1):304.