Looking through these issues, the devteam for this project looks so unhelpful and uncooperative when it comes to the topic of the PythonDLL.

No, Python.Runtime.PythonDLL can't be set as it's a readonly, same with Python.Runtime.Runtime.PythonDLL
No, the exception does not make sense as even users who have clearly tried everything to set it have had no luck. Notable response: "The exception is very explicit" followed by the closing of the thread.

Clearly the people asking about how to resolve the exception annoy you, so why won't you just add the info to the README? If the only way to set the PythonDLL is using the environment variables, then just say that's the only way. It's either that or link whatever solution youthink works when responding to similar issues before closing them.

TO REITERATE: 'Runtime.PythonDLL' 'Python.Runtime.PythonDLL' AND 'Python.Runtime.Runtime.PythonDLL' ARE SET AS READONLY