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Phylogenetic analysis of multi-species genome sequence alignments to identify conserved protein-coding regions

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mlin/PhyloCSF

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  +---------------------------------------------------------------------+  |             ____  __          __       ___________ ______           |  |            / __ \/ /_  __  __/ /____  / ____/ ___// ____/           |  |           / /_/ / __ \/ / / / // __ \/ /    \__ \/ /_               |  |          / ____/ / / / /_/ / // /_/ / /___ ___/ / __/               |  |         /_/   /_/ /_/\__, /_/ \____/\____//____/_/                  |  |                      /____/                                         |  |                                                                     |  |http://compbio.mit.edu/PhyloCSF                     |   +---------------------------------------------------------------------+SOURCE DISTRIBUTIONPlease see our web site for more information about PhyloCSF and how to use it.PhyloCSF is written in OCaml. This source distribution is divided into alibrary, CamlPaml, containing generic infrastructure for phylogenetic ratemodels, and a program implementing the PhyloCSF-specific models and driverprogram. With additional development, the CamlPaml library will eventually bereleased as a separate entity, but for now it is just part of thisdistribution.Here are the steps to build the source:[1] Install the OCaml package manager OPAMhttp://opam.ocamlpro.com/doc/Quick_Install.htmlThis will install a minimal OCaml toolchain (if not already present on yoursystem) and the OPAM package manager. Once it's installed, initialize yourshell environment by running: eval $(opam config env)[2] Install dependencies using OPAMopam install batteries ocaml+twt gslThe gsl package may require you to separately install the GNU ScientificLibrary (GSL) from:http://www.gnu.org/software/gsl/On Debian/Ubuntu systems GSL is available in the 'libgsl0-dev' package, and onMac OS X, 'gsl' is available in both Homebrew and MacPorts.[3] Compile PhyloCSFNow just run 'make' in this directory. This will build and install theCamlPaml library, then compile the PhyloCSF executable and copy it tothis directory. You can then use the ./PhyloCSF dispatch script like theexamples found on our website, e.g../PhyloCSF 12flies PhyloCSF_Examples/tal-AA.faPhyloCSF should be usable in this way by anyone on the machine/cluster with rxpermissions; they don't have to set up OPAM or anything else. PhyloCSF canbe started from any working directory.If you want to 'install' PhyloCSF somewhere, you must transplant PhyloCSF,PhyloCSF.ARCH (where e.g. ARCH=Linux.x86_64), and the PhyloCSF_Parametersdirectory to the desired location.

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Phylogenetic analysis of multi-species genome sequence alignments to identify conserved protein-coding regions

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