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This is brutal amount of latency when trying to provide a smooth user experience from an application that uses matplotlib internally.
In [1]: %prun -r -s cumtime -l 20 import matplotlib.pyplotncalls tottime percall cumtime percall filename:lineno(function) 1 0.002 0.002 2.461 2.461 <string>:1(<module>) 1 0.001 0.001 2.413 2.413 pyplot.py:17(<module>) 1 0.001 0.001 2.392 2.392 colorbar.py:20(<module>) 1 0.001 0.001 2.380 2.380 collections.py:10(<module>) 1 0.002 0.002 2.374 2.374 backend_bases.py:28(<module>) 1 0.001 0.001 2.365 2.365 textpath.py:3(<module>) 1 0.001 0.001 2.362 2.362 font_manager.py:21(<module>) 1 0.000 0.000 2.361 2.361 font_manager.py:952(pickle_load) 1 0.003 0.003 2.361 2.361 {cPickle.load} 1 0.001 0.001 2.358 2.358 font_manager.py:1013(__init__) 2 0.098 0.049 2.275 1.137 font_manager.py:544(createFontList) 215 0.000 0.000 2.149 0.010 afm.py:341(__init__) 215 0.001 0.000 2.148 0.010 afm.py:323(parse_afm) 215 0.001 0.000 1.443 0.007 afm.py:292(_parse_optional) 182 0.979 0.005 1.434 0.008 afm.py:220(_parse_kern_pairs) 215 0.374 0.002 0.690 0.003 afm.py:180(_parse_char_metrics) 1298020 0.229 0.000 0.229 0.000 {method 'split' of 'str' objects} 839978 0.157 0.000 0.157 0.000 {method 'readline' of 'file' objects} 114276 0.087 0.000 0.107 0.000 afm.py:72(_to_list_of_floats) 843180 0.092 0.000 0.092 0.000 {method 'startswith' of 'str' objects} 4 0.000 0.000 0.082 0.021 font_manager.py:294(findSystemFonts)q