When migrating from Underscore to Lodash there are several differences to be aware of.
Below are some of the ones that stand out. For a more thorough guide check outlodash-codemods,eslint-plugin-lodash &Underscore to Lodash Converter.

• Underscore_.any is Lodash_.some
• Underscore_.all is Lodash_.every
• Underscore_.compose is Lodash_.flowRight
• Underscore_.contains is Lodash_.includes
• Underscore_.each doesn’t allow exiting by returningfalse is Lodash_.forEach
• Underscore_.escape escapes backtick characters ('`'), while Lodash does not
• Underscore_.findWhere is Lodash_.find
• Underscore_.flatten is deep by default while Lodash is shallow
• Underscore_.groupBy's iteratee receives the argumentsvalue,indexNumber, andoriginalCollection, while Lodash_.groupBy's iteratee receives only the argumentvalue
• Underscore_.indexOf with 3rd parameterundefined is Lodash_.indexOf
• Underscore_.indexOf with 3rd parametertrue is Lodash_.sortedIndexOf
• Underscore_.indexBy is Lodash_.keyBy
• Underscore_.invoke is Lodash_.invokeMap
• Underscore_.mapObject is Lodash_.mapValues
• Underscore_.max combines Lodash_.max &_.maxBy
• Underscore_.min combines Lodash_.min &_.minBy
• Underscore_.sample combines Lodash_.sample &_.sampleSize
• Underscore_.object combines Lodash_.fromPairs and_.zipObject
• Underscore_.omit by a predicate is Lodash_.omitBy
• Underscore_.pairs is Lodash_.toPairs
• Underscore_.pick by a predicate is Lodash_.pickBy
• Underscore_.pluck is Lodash_.map
• Underscore_.sortedIndex with an iteratee is Lodash_.sortedIndexBy, which doesn't take a 4th (context) parameter.
• Underscore_.uniq by aniteratee is Lodash_.uniqBy._.uniq with theisSorted parameter = true is Lodash_.sortedUniq (or Lodash_.sortedUniqBy when using an iteree).
• Underscore_.unique alias for_.uniq does not exist in Lodash
• Underscore_.where is Lodash_.filter
• Underscore_.isFinite doesn’t align withNumber.isFinite
  (e.g._.isFinite('1') returnstrue in Underscore butfalse in Lodash)
• Underscore_.matches shorthand doesn’t support deep comparisons
  (e.g._.filter(objects, { 'a': { 'b': 'c' } }))
• Underscore ≥ 1.7 & Lodash_.template syntax is
  _.template(string, option)(data)
• Lodash_.memoize caches areMap like objects
• Lodash doesn’t support acontext argument for many methods in favor of_.bind
• Lodash supportsimplicit chaining,lazy chaining, & shortcut fusion
• Lodash split its overloaded_.head,_.last,_.rest, &_.initial out into
  _.take,_.takeRight,_.drop, &_.dropRight
  (i.e._.head(array, 2) in Underscore is_.take(array, 2) in Lodash)

Lodash works great with Backbone. It’s even run against Backone’s unit tests on every commit.
You can replace Underscore with Lodash in Backbone by using anAMD loader,browserify, orwebpack.

Note: Lodash v4 works with Backbone ≥ v1.3.0.

• Using AMD “paths” configuration

require({'paths'{'backbone':'path/to/backbone','jquery':'path/to/jquery','underscore':'path/to/lodash'}},['backbone'],function(Backbone){// use Backbone});

• Using thealiasify transform for browserify by adding a section to your package.json

{"browserify": {"transform": ["aliasify"]  },"aliasify": {"aliases": {"underscore":"lodash"    }  }}

and executing browserify with thealiasify parameter

$ browserify entry.js --global-transform aliasify -o out.js

• Using theresolve.alias configuration in webpack

module.exports={'resolve':{'alias':{'underscore':'absolute/path/to/lodash'}}};