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Extracting human gene families from HGNC

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dhimmel/hgnc

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This repository processes thegene family data from HGNC. In the future, the repository may expand its scope to process other types of HGNC data.

Notebooks

  • 1.download.ipynb downloads HGNC data. Check this notebook to see the last modified dates of downloaded files.
  • 2.families.ipynb constructs the gene family ontology innetworkx. Annotates gene families with their corresponding Entrez Gene IDs. Gene membership in a family is propagated, e.g. genes belonging to the "Glutamate metabotropic receptors" family also belong to the "Glutamate receptors" family.

Files & Directories

  • download contains unmodified downloads from the EBI FTP site.
  • data contains generated datasets.families.graphml contains a GraphML-formatted network of the HGNC gene family ontology.gene-families.tsv contains the mapping between gene families and Entrez genes.

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