Eclipse JEE Oxygen provides SourceMap debugging support (see bug487465) with JSDT Debugger with classicRun / Debug as.

If you useEclipse JEE Oxygen, you can run/debug TypeScript withEclipse JEE Oxygen if *.js.map SourceMap files is generated.

The JSDT SourceMap debugging support is not perfect, but it starts working. Please create bugs at Eclipse bugzilla JSDT.

You can too installWebclipse which provides a debugger for TypeScript.