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PKPDsim is a library for numerical integration of ODE systems, in particular pharmacokinetic-pharmacodynamic (PK-PD) mixed-effects models.

The development version of PKPDsim always has the most up-to-date improvementsand bug fixes. We aim to release PKPDsim on CRAN at least once a year,depending on the number and impact of updates made to the development version.

TheCRAN version of PKPDsim can be installed using:

install.packages("PKPDsim")

The development version of PKPDsim can be installed fromGitHub orR-universe using:

# Install from GitHub:devtools::install_github("InsightRX/PKPDsim")# Install from R-universe:install.packages("PKPDsim",repos="https://insightrx.r-universe.dev")

A number of models from the literature have been made available for use inPKPD simulations. To see which models are available for installation, run:

available_default_literature_models()

You can install these models as packages using the following commands:

# To install a single model:install_default_literature_model("pk_busulfan_mccune")# To install all supplied models:install_default_literature_model("all")

We welcome input from the community:

• If you think you have encountered a bug, pleasesubmit an issueon the GitHub page. Please include a reproducible example of the unexpectedbehavior.

• Pleaseopen a pull request ifyou have a fix or updates that would improve the package. If you're not sure ifyour proposed changes are useful or within scope of the package, feel free tocontact one of the authors of this package.

The functionality in this R package is provided "as is". While its authorsadhere to software development best practices, the software may still containunintended errors.

InsightRX Inc. and the authors of this package can not be held liable for anydamages resulting from any use of this software. By the use of this softwarepackage, the user waives all warranties, expressed or implied, including anywarranties to the accuracy, quality or suitability of InsightRX for anyparticular purpose, either medical or non-medical.

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