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FB2025_05,released December 11, 2025
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FlyBase NIH Grant Terminated
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FB2025_05,released December 11, 2025
Gene: Dmel\Dsor1
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General Information
Symbol
Dmel\Dsor1
Species
D. melanogaster
Name
Downstream of raf1
Annotation Symbol
CG15793
Feature Type
FlyBase ID
FBgn0010269
Gene Model Status
Stock Availability
Enzyme Name (EC)
mitogen-activated protein kinase kinase (2.7.12.2)
Gene Summary
Downstream of raf1 (Dsor1) encodes a serine/threonine kinase that phosphorylates MAP kinase. It is activated by the product ofRaf and acts downstream of receptor tyrosine kinases such as those encoded bytor,Egfr, andsev. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

MEK, Dsor, MAPKK, D-mek, DRODSOR1

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
1-27
RefSeq locus
NC_004354 REGION:9247342..9250037
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (26 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction withUniProtKB:P11346,UniProtKB:Q24171
inferred from direct assay
inferred from genetic interaction withSGD:S000004354
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Biological Process (20 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
inferred from genetic interaction withFLYBASE:sl;FB:FBgn0003416
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction withFLYBASE:fs(1)K10;FB:FBgn0000810
inferred from genetic interaction withFLYBASE:Egfr;FB:FBgn0003731
inferred from genetic interaction withFLYBASE:fs(1)K10;FB:FBgn0000810
inferred from high throughput genetic interaction withFLYBASE:Ras85D;FB:FBgn0003205
inferred from genetic interaction withFLYBASE:rl;FB:FBgn0003256
inferred from mutant phenotype
inferred from genetic interaction withFLYBASE:hop;FB:FBgn0004864
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction withUniProtKB:P51023
inferred from genetic interaction withFLYBASE:Ras85D;FB:FBgn0003205
inferred from mutant phenotype
inferred from genetic interaction withFLYBASE:Ras85D;FB:FBgn0003205
inferred from genetic interaction withFLYBASE:sev;FB:FBgn0003366
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction withFLYBASE:tor;FB:FBgn0003733
inferred from mutant phenotype
inferred from genetic interaction withFLYBASE:rl;FB:FBgn0003256
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_inMAPK cascade
inferred from biological aspect of ancestor withPANTHER:PTN000684494
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
colocalizes_withnuclear envelope
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (Q24324)
Catalytic Activity (EC/Rhea)
MAP kinase kinase activity
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.12.2)
(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.12.2)
(3) L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) (2.7.12.2)
Summaries
Gene Snapshot
Downstream of raf1 (Dsor1) encodes a serine/threonine kinase that phosphorylates MAP kinase. It is activated by the product ofRaf and acts downstream of receptor tyrosine kinases such as those encoded bytor,Egfr, andsev. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
STE7 MAP KINASE KINASES -
STE7 MAP kinase kinases (MAPKKs) belong to the STE7 subfamily and are serine/threonine kinases that phosphorylate MAP kinases in MAPK signalling cascades. MAPKKs are activated by MAP kinase kinase kinases (MAPKKKs). (Adapted fromFBrf0225276.)
Pathway (FlyBase)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted fromFBrf0232297,FBrf0230017 andFBrf0229989.)
TORSO SIGNALING PATHWAY CORE COMPONENTS -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted fromFBrf0157176.)
SEVENLESS SIGNALING PATHWAY CORE COMPONENTS -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression oflz andpros.sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted fromFBrf0127283 andFBrf0221727).
EGFR SIGNALING PATHWAY CORE COMPONENTS -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinaseEgfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted fromFBrf0190321 andFBrf0221727).
FGFR SIGNALING PATHWAY CORE COMPONENTS -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs -bnl orths/pyr to receptor tyrosine kinasesbtl orhtl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted fromFBrf0221038).
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 orPvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764,FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted fromFBrf0222697 andFBrf0221727).
Protein Function (UniProtKB)
Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.
(UniProt,Q24324)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view ofDmel\Dsor1 for information on other features

To submit a correction to a gene model please use theContact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted byAlphaFold)   (AlphaFold entry Q24324)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071313
1799
396
FBtr0340120
1503
393
Additional Transcript Data and Comments
Reported size (kB)

2.0 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0071248
43.9
396
6.25
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

393 (aa); 44 (kD)

Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Raf and ksr; Dsor1 binding to ksr probably promotes ksr and Raf dimerization and ksr-mediated Raf transactivation.

(UniProt,Q24324)
Post Translational Modification

Phosphorylation on Ser/Thr by MAP kinase kinase kinases regulates positively the kinase activity.

(UniProt,Q24324)
Crossreferences
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dsor1 using theFeature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data byVedeleket al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment:maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Dsor1 transcripts are expressed throughout development and are particularly abundant in early embryos.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
colocalizes_withnuclear envelope
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

ViewDmel\Dsor1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
SeeGelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
Dsor1
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dsor1
Transgenic constructs containing regulatory region of Dsor1
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (42)
13 of 14
Yes
Yes
12 of 14
No
Yes
Hsap\LOC407835
7 of 14
No
Yes
5 of 14
No
Yes
2 of 14
No
No
1  
2 of 14
No
No
2 of 14
No
No
1  
2 of 14
No
No
2 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
6  
1 of 14
No
No
1  
1 of 14
No
No
2  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (33)
13 of 14
Yes
Yes
12 of 14
No
Yes
5 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (32)
13 of 14
Yes
Yes
12 of 14
No
Yes
5 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
10 of 13
Yes
Yes
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Danio rerio (Zebrafish) (29)
13 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
5 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (25)
13 of 14
Yes
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (18)
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (42)
11 of 13
Yes
Yes
11 of 13
Yes
Yes
10 of 13
No
Yes
7 of 13
No
Yes
4 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
8 of 13
Yes
Yes
7 of 13
No
Yes
7 of 13
No
Yes
5 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
11 of 12
Yes
Yes
5 of 12
No
Yes
4 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Dsor1. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (18)
4 of 13
4 of 13
2 of 13
2 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 12 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 9 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with Raf and ksr; Dsor1 binding to ksr probably promotes ksr and Raf dimerization and ksr-mediated Raf transactivation.
(UniProt,Q24324 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-27
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
8D2-8D3
Limits computationally determined from genome sequence betweenP{EP}EP1450&P{EP}EP1356 andP{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
8D-8D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (23)
Genomic Clones (7)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please seeJBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      dsRNA made from templates generated with primers directed against this gene.

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      The MAPK cascade is required forRas85D mitogenic response, loss of function mutations inphl,Dsor1,rl andksr dominantly suppress hyperplastic growth, as do mutations in theRas85D effector loop that disrupt theRas85D-phl interaction.

      Downstream signal transducer of torso, sevenless and DER receptors.

      Studies of interaction betweenargos and members of the Ras/MAPK pathway demonstrate theargos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade.

      Expression ofDsor1 in lin-3, let-23 or lin-45C.elegans mutants permits P5.p, P6.p and P7.p segments to adopt the vulval fates in each of the vulvaless backgrounds.

      Additional alleles ofDsor1 have been isolated in screen for lethal mutations that fail to complementDf(1)10-70d.

      A screen to identify mutations affecting theRas85D signalling pathway identified alleles ofphl,Dsor1,rl,aop,βggt-I,mts,ksr andphyl.

      Down-regulation ofbcd activity depends on the function ofDsor1.Dsor1 acts downstream ofphl in thetor pathway and encodes a MAP-kinase kinase (MAPKK). Several clustered consensus sites for MAP kinase phosphorylation can be found in thebcd coding sequence.

      Dsor1 acts downstream ofphl in the DER pathway.

      Dsor1 andphl both play a role in the determination of the rate of proliferation. Maternally derivedDsor1 is required for development of the embryonic termini.Dsor1 is involved in both the positive and negative regulation oftll.

      Relationship to Other Genes
      Source for database merge of
      Additional comments

      Wild-typeDsor1 does not complement the mating defect ofS.cerevisiaeScer\ste7 mutants. A mutated form ofDsor1 (carrying the lesion found inDsor1Su1) does complement the mating defect ofS.cerevisiaeScer\ste7 mutants. Wild-typeDsor1 does not complement the temperature-sensitive cell-lysis defect ofS.cerevisiaeScer\MKK1Scer\MKK2 double mutants. A mutated form ofDsor1 (carrying the lesion found inDsor1Su1) does complement the temperature-sensitive cell-lysis defect ofS.cerevisiaeScer\MKK1Scer\MKK2 double mutants. Wild-typeDsor1 or a mutated form ofDsor1 (carrying the lesion found inDsor1Su1) does not complement the sensitivity to osmotic pressure ofS.cerevisiaeScer\pbs2 mutants.

      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (47)
      Reported As
      Symbol Synonym
      D-MEK/Dsor
      Dsor1
      (Fukuda et al., 2024,Koehler et al., 2024,Rodríguez-Martín et al., 2024,Andrianova et al., 2023,Sekiya et al., 2023,Perlegos et al., 2022,Zhao et al., 2022,Bilder et al., 2021,DeAngelis et al., 2021,Fabian et al., 2021,Harnish et al., 2021,Khan et al., 2021,Lebo et al., 2021,Marmion et al., 2021,Nguyen et al., 2021,Ostalé et al., 2021,Yu et al., 2021,Zheng et al., 2021,Alameh et al., 2020,Graves et al., 2020,Hayashi and Ogura, 2020,Kierdorf et al., 2020,Kurihara et al., 2020,Wang et al., 2020,Chai et al., 2019,Fenckova et al., 2019,Zirin et al., 2019,Das et al., 2018,Du et al., 2018,Gene Disruption Project members, 2018-,Inoue et al., 2018,Lee et al., 2018,Levis, 2018.8.30,Muñoz-Soriano et al., 2018,Ashton-Beaucage and Therrien, 2017,Goyal et al., 2017,Houtz et al., 2017,Jindal et al., 2017,Lusk et al., 2017,Song et al., 2017,Transgenic RNAi Project members, 2017-,Ashton-Beaucage et al., 2016,Malartre, 2016,Hall and Verheyen, 2015,Li et al., 2015,Zang et al., 2015,Chuang et al., 2014,Gonzalez et al., 2014,Hasygar and Hietakangas, 2014,Kim et al., 2014,Sopko et al., 2014,Bergwitz et al., 2013,Carter, 2013,Chen et al., 2013,Cui et al., 2013,Mbodj et al., 2013,Park et al., 2013,Schertel et al., 2013,Walker et al., 2013,Yamamoto et al., 2013-,Yin et al., 2013,Gomez et al., 2012,Legent et al., 2012,Miller et al., 2012,Friedman et al., 2011,Friedman et al., 2011,Friedman et al., 2011,Maher et al., 2011,Ragab et al., 2011,Zeng et al., 2010,Hill-Burns and Clark, 2009,Sims et al., 2009,Christensen et al., 2008.6.11,Christensen et al., 2008.6.11,Christensen et al., 2008.12.28,Mouchel-Vielh et al., 2008,Xia et al., 2008,Zhou et al., 2008,Nishimura et al., 2007,Nishimura et al., 2007,Guichard et al., 2006,Mogila et al., 2006,Oishi et al., 2006,Walker et al., 2006,Michellod et al., 2003,Dawes-Hoang and Wieschaus, 2001,Lim et al., 1997)
      MEK
      (Maisonneuve et al., 2024,Ureña et al., 2024,Yang et al., 2024,Andrianova et al., 2023,Sekiya et al., 2023,Zhang et al., 2022,Øvrebø et al., 2022,Marmion et al., 2021,Valon et al., 2021,Koyama et al., 2020,Mariano et al., 2020,Paul et al., 2020,Sun et al., 2020,Johnson and Toettcher, 2019,Wittes and Schüpbach, 2019,Zhang et al., 2019,Inoue et al., 2018,Lavoie et al., 2018,Goyal et al., 2017,Lusk et al., 2017,Jin et al., 2015,Sopko et al., 2015,Pichaud, 2014,Bergwitz et al., 2013,Yu et al., 2013,Miller et al., 2012,Herr et al., 2010,Majumdar et al., 2010,Roignant and Treisman, 2010,Tipping et al., 2010,Nie et al., 2009,Mouchel-Vielh et al., 2008,Ashton-Beaucage and Therrien, 2007,Mogila et al., 2007,Douziech et al., 2006,Kim et al., 2006,Mogila and Li, 2006,Mogila et al., 2006,Vrailas et al., 2006,Walker et al., 2006,Harrison et al., 2005,Douziech et al., 2003,Anselmo et al., 2002,Castelli-Gair Hombria and Brown, 2002,Rebay, 2002,Roy and Therrien, 2002,Roy et al., 2002,Yokokura et al., 2002,Kumar and Moses, 2001,Kumar and Moses, 2001,Morrison et al., 2000,Duffy et al., 1998,Karim and Rubin, 1998,Lu and Li, 1998,Perrimon and Duffy, 1998,Karim et al., 1997,Badenhorst et al., 1996,Klämbt et al., 1996,Avruch et al., 1994)
      Su(Raf)34B
      Name Synonyms
      Downstream of Raf1
      Drosophila MEK
      MAP Kinase Kinase
      MAPK kinase
      Map kinase kinase
      downstream suppressor of Raf 1
      mitogen-activated protein kinase kinase
      Secondary FlyBase IDs
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 125 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        PDB - An information portal to biological macromolecular structures
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (349)

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