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FB2025_05,released December 11, 2025
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FB2025_05,released December 11, 2025
Gene: Dmel\Pp1-87B
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General Information
Symbol
Dmel\Pp1-87B
Species
D. melanogaster
Name
Protein phosphatase 1 at 87B
Annotation Symbol
CG5650
Feature Type
FlyBase ID
FBgn0004103
Gene Model Status
Stock Availability
Enzyme Name (EC)
protein-serine/threonine phosphatase (3.1.3.16)
Gene Summary
Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase. (UniProt,P12982)
Contribute a Gene Snapshot for this gene.
Also Known As

Su(var)3-6, PP1α87B, PP1, Su-var(3)6, PP1 87B

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-52
RefSeq locus
NT_033777 REGION:12423621..12425917
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Biological Process (19 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
involved_inaxon guidance
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_inoogenesis
inferred from mutant phenotype
involved_inspindle assembly
inferred from mutant phenotype
involved_invisual learning
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
non-traceable author statement
involved_inlocomotion
non-traceable author statement
inferred from sequence or structural similarity withUniProtKB:P62138
inferred from sequence or structural similarity withUniProtKB:P62138
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_incytoplasm
inferred from biological aspect of ancestor withPANTHER:PTN000185233
is_active_innucleus
inferred from biological aspect of ancestor withPANTHER:PTN000185231
Protein Family (UniProt)
Belongs to the PPP phosphatase family. PP-1 subfamily. (P12982)
Catalytic Activity (EC/Rhea)
protein serine/threonine phosphatase activity
(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)
(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)
myosin phosphatase activity
(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)
(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)
Summaries
Gene Group (FlyBase)
PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -
The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted fromPMID:11230548 andPMID:19879837).
PTW-PP1 COMPLEX PP1-87B VARIANT -
A nuclear protein serine/threonine phosphatase complex that regulates gene expression. The core of the complex is formed by a protein phosphatase 1 catalytic subunit and the scaffolding/nuclear-targeting subunitPNUTS. (Adapted fromFBrf0262508 andPMID:20516061.)
Pathway (FlyBase)
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
POSITIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted fromFBrf0232297,FBrf0230017 andFBrf0229989).
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of theMad/Med transcription factor complex.
Protein Function (UniProtKB)
Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase.
(UniProt,P12982)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(3)87Bg
Hemizygotes for l(3)87Bg2 form fully-pigmented pharate adults. Viability reduced in certain trans heterozygotes with Su(var)3-61; several l(3)87Bg/+ genotypes suppress position-effect variegation (Reuter et al.).
Pp1: Protein phosphatase 1
Encodes a protein phosphatase 1 catalytic subunit that shows a high degree of similarity to rabbit protein phosphatase 1α in its enzymatic and physiochemical characteristics and has a predicted protein sequence that is 92% identical to that of rabbit PP-1α.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view ofDmel\Pp1-87B for information on other features

To submit a correction to a gene model please use theContact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted byAlphaFold)   (AlphaFold entry P12982)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0082595
2203
302
Additional Transcript Data and Comments
Reported size (kB)

2.5, 1.6 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0082067
34.5
302
5.26
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

302 (aa); 34.5 (kD predicted)

Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Nop17l (PubMed:17007873). Interacts with uri; uri inhibits Pp1-87B phosphatase activity (PubMed:18412953). Interacts with Rif1 (PubMed:26022086,PubMed:29746464).

(UniProt,P12982)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pp1-87B using theFeature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data byVedeleket al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.66

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

The 1.6 and 2.5 kbPp1-87B transcripts are present thoroughout development.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
epitope tag
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

ViewDmel\Pp1-87B in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
SeeGelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
Pp1-87B
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pp1-87B
Transgenic constructs containing regulatory region of Pp1-87B
Aberrations (Deficiencies and Duplications) ( 51 )
Inferred from experimentation ( 51 )
Gene disrupted in
Gene not disrupted in
Inferred from location ( 13 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
mitosis & nuclear chromosome
photoreceptor cell R1 & axon, withScer\GAL4GMR.PF
photoreceptor cell R1 & axon (withPp1-87B87Bg-1)
photoreceptor cell R1 & axon (withPp1-87B87Bg-3)
photoreceptor cell R1 & axon (withPp1-87B87Bg-6)
photoreceptor cell R2 & axon, withScer\GAL4GMR.PF
photoreceptor cell R2 & axon (withPp1-87B87Bg-1)
photoreceptor cell R2 & axon (withPp1-87B87Bg-3)
photoreceptor cell R2 & axon (withPp1-87B87Bg-6)
photoreceptor cell R3 & axon, withScer\GAL4GMR.PF
photoreceptor cell R3 & axon (withPp1-87B87Bg-1)
photoreceptor cell R3 & axon (withPp1-87B87Bg-3)
photoreceptor cell R3 & axon (withPp1-87B87Bg-6)
photoreceptor cell R4 & axon, withScer\GAL4GMR.PF
photoreceptor cell R4 & axon (withPp1-87B87Bg-1)
photoreceptor cell R4 & axon (withPp1-87B87Bg-3)
photoreceptor cell R4 & axon (withPp1-87B87Bg-6)
photoreceptor cell R5 & axon, withScer\GAL4GMR.PF
photoreceptor cell R5 & axon (withPp1-87B87Bg-1)
photoreceptor cell R5 & axon (withPp1-87B87Bg-3)
photoreceptor cell R5 & axon (withPp1-87B87Bg-6)
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
13 of 14
Yes
Yes
1  
13 of 14
Yes
Yes
2  
7 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
2  
3 of 14
No
No
1  
3 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (14)
13 of 14
Yes
Yes
12 of 14
No
Yes
7 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
Mus musculus (laboratory mouse) (14)
13 of 14
Yes
Yes
11 of 14
No
Yes
7 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
2 of 14
No
Yes
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (16)
11 of 13
Yes
Yes
5 of 13
No
No
3 of 13
No
No
3 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Danio rerio (Zebrafish) (18)
13 of 14
Yes
Yes
12 of 14
No
No
12 of 14
No
No
7 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
3 of 14
No
No
2 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (48)
12 of 14
Yes
Yes
7 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
7 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
No
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
6 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
5 of 14
No
Yes
4 of 14
No
No
4 of 14
No
No
4 of 14
No
No
4 of 14
No
Yes
4 of 14
No
Yes
4 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
No
3 of 14
No
Yes
3 of 14
No
Yes
2 of 14
No
Yes
2 of 14
No
Yes
2 of 14
No
No
2 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (9)
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (35)
12 of 13
Yes
No
12 of 13
Yes
Yes
10 of 13
No
Yes
10 of 13
No
Yes
10 of 13
No
No
9 of 13
No
Yes
7 of 13
No
Yes
6 of 13
No
Yes
6 of 13
No
Yes
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
No
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (13)
11 of 13
Yes
No
5 of 13
No
Yes
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
4 of 13
No
No
3 of 13
No
No
3 of 13
No
No
2 of 13
No
No
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (11)
11 of 12
Yes
Yes
9 of 12
No
Yes
4 of 12
No
No
4 of 12
No
No
4 of 12
No
No
4 of 12
No
Yes
3 of 12
No
No
3 of 12
No
No
2 of 12
No
No
1 of 12
No
Yes
Escherichia coli (enterobacterium) (3)
2 of 11
Yes
No
2 of 11
Yes
No
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pp1-87B. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (19)
12 of 13
12 of 13
11 of 13
7 of 13
6 of 13
6 of 13
6 of 13
6 of 13
5 of 13
5 of 13
5 of 13
4 of 13
4 of 13
3 of 13
3 of 13
3 of 13
3 of 13
3 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    Interaction Browsers
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Nop17l (PubMed:17007873). Interacts with uri; uri inhibits Pp1-87B phosphatase activity (PubMed:18412953). Interacts with Rif1 (PubMed:26022086,PubMed:29746464).
    (UniProt,P12982 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-52
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    87B9-87B10
    Limits computationally determined from genome sequence betweenP{PZ}svp07842 andP{lacW}Vha55j2E9
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    87B10-87B13
    (determined by in situ hybridisation)
    87B6-87B12
    (determined by in situ hybridisation)
    Location based on deficiency mapping.
    Experimentally Determined Recombination Data
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (10)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (229)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please seeJBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or withoutCdc27 dsRNA.

        S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

        In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

        neb protein bindsPp1-87B protein in vitro.

        Mutants block mitosis, alter heterochromatin and cause pupal lethality.

        Flies deficient for protein phosphatase 1 show behavioral abnormalities, with impaired associative olfactory learning and visual conditioning. Also reduced mobility and flight activity.

        Pp1-87B gene product is essential for germline development.

        A haplo-dependent suppressor of position effect variegation without the triplo enhancer effect, flies with two additional copies show normal mottling.

        Pp1-87B regulates the condensation state of chromatin during interphase.

        Encodes a serine/threonine specific protein phosphatase.

        Suppression ofIn(1)wm4 position effect variegation byPp1-87B was not reversed by a supernumerary copy ofSu(var)3-7.

        Identification: Isolated from a Drosophila head cDNA library, using a rabbit muscle PP-1α cDNA as a probe.

        Duplications ofPp1-87B were found to considerably reduce the haplo-abnormal effect of heterozygousPp1-87B point mutations.

        Relationship to Other Genes
        Source for database merge of

        Source for merge of: Pp1-87B l(3)j6E7

        Source for merge of: Pp1-87B CG5650

        Additional comments

        ThePp1-87B gene may have been derived from a related phosphoprotein phosphatase gene by retroposition.

        ThePp1-87B gene may have been derived from thePp1α-96A gene by retroposition.

        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (44)
        Reported As
        Symbol Synonym
        Pp-1α
        Pp1-87B
        (Avila et al., 2024,Perlegos et al., 2023,Chang et al., 2022,Khoury and Bilder, 2022,Ibaraki et al., 2021,Ostalé et al., 2021,Parkhitko et al., 2021,Machyna et al., 2020,Zhao et al., 2020,Deneke et al., 2019,Wang et al., 2019,Miyashita et al., 2018,Muñoz-Soriano et al., 2018,Ashton-Beaucage and Therrien, 2017,Roubinet et al., 2017,Brewer-Jensen et al., 2016,Schwartz et al., 2016,Di Cara et al., 2015,Sreesankar et al., 2015,Ashton-Beaucage et al., 2014,dos Santos, 2014,Kerekes et al., 2014,Sopko et al., 2014,White-Grindley et al., 2014,Bonke et al., 2013,Schertel et al., 2013,Friedman et al., 2011,Guruharsha et al., 2011,Lindquist et al., 2011,Miskei et al., 2011,Rees et al., 2011,Strübbe et al., 2011,Bai et al., 2009,Christensen et al., 2009.7.22,Cook et al., 2009.2.28,Nie et al., 2009,Bakal et al., 2008,Puri et al., 2008,Bai et al., 2007,Bai et al., 2007,Chen et al., 2007,Diaz-Castillo and Golic, 2007,Goshima et al., 2007,Kirchner, 2007.7.19,Kirchner, 2007.7.29,Kirchner et al., 2007,Dorus et al., 2006,Stroschein-Stevenson et al., 2006,Stanyon et al., 2004,Wang et al., 2004,Wheeler et al., 2004)
        Pp1α-87B
        Su(var)(3)6
        l(3)87Bg
        su-var(3)6
        Name Synonyms
        Protein phosphatase 1
        Protein phosphatase 1 at 87B
        Suppressor of variegation
        protein phosphatase 1
        protein phosphatase 1 at 87B
        Secondary FlyBase IDs
        • FBgn0002338
        • FBgn0003133
        • FBgn0003597
        • FBgn0010090
        • FBgn0011795
        • FBgn0038044
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 46 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (246)

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