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General Information

Symbol

Dmel\hep^GL00089

Species

D. melanogaster

Name

FlyBase ID

FBal0262574

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00089}

Also Known As

UAS-hepRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00089}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00089

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates hematologic cancer

modeled bymxc¹

(Kinoshita et al., 2024)

ameliorates hematologic cancer

modeled bymxc¹

(Takarada et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile, withScer\GAL4^{VP16.nanos.UTR},Scer\GAL4^VP16.otu,Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

embryo |maternal effect, withScer\GAL4^{VP16.nanos.UTR},Scer\GAL4^VP16.otu,Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Detailed Description

Statement

Reference

Females heterozygous forhep^GL00089 and MTD-Gal4 (consists ofScer\GAL4^{otu.T:Hsim\VP16},Scer\GAL4^nos.PG andScer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed tohep^GL00089 males results in: 0% hatching; egg/embryonic phenotype: dorsal closure defects; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

hep^GL00089/Scer\GAL4^He.PZ is a suppressor ofpseudopodium |increased number |larval stage phenotype ofmxc¹

(Takarada et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35210

y¹ sc^* v¹ sev²¹; P{TRiP.GL00089}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hep^GL00089

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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