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General Information

Symbol

Dmel\fbl^L.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0246209

Feature type

allele

Associated gene

Dmel\fbl

Associated Insertion(s)

Carried in Construct

P{UAS-fbl.L}

Key Links

Transgenic product class

wild_type

(Wu et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wu et al., 2009)

Mutagen

in vitro construct

(Wu et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-fbl.L}

Cytology

Description

UAS regulatory sequences drive expression of the long isoform offbl (known asfbl-RE in FlyBase).

(Wu et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

fbl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 6

modeled byPink1^RNAi.UAS.cYa

(Huang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Act.PU/fbl^L.UAS rescuesfbl¹

(Wu et al., 2009)

Partially rescues

Scer\GAL4^elav.PU/fbl^L.UAS partially rescuesfbl¹

(Wu et al., 2009)

fbl^L.UAS/Scer\GAL4^Ddc.PL partially rescuesfbl¹

(Wu et al., 2009)

fbl^L.UAS/Scer\GAL4^ChAT.7.4 partially rescuesfbl¹

(Wu et al., 2009)

Comments

Expression offbl^L.Scer\UAS under the control ofScer\GAL4^Act.PU rescues the eclosion defects offbl¹ flies, and the lifespan of these animals recovers to almost normal levels. Locomotor and infertility defects are also rescued in these animals.

Expression offbl^L.Scer\UAS under the control ofScer\GAL4^elav.PU in afbl¹ mutant background rescues the eclosion defects, shortened lifespan and movement coordination defects offbl¹ flies, but does not rescue infertility.

Expression offbl^L.Scer\UAS in dopaminergic neurons under the control ofScer\GAL4^Ddc.PL partially rescues the eclosion rate, shortened lifespan, and locomotor defects offbl¹ mutant flies.

Expression offbl^L.Scer\UAS in cholinergic neurons under the control ofScer\GAL4^Cha.7.4 partially rescues the eclosion rate, shortened lifespan, and locomotor defects offbl¹ mutant flies.

(Wu et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fbl^L.Scer\UAS

fbl^L.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

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