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General Information

Symbol

Dmel\Xbp1^UAS.RB

Species

D. melanogaster

Name

FlyBase ID

FBal0230352

Feature type

allele

Associated gene

Dmel\Xbp1

Associated Insertion(s)

Carried in Construct

P{UAS-Xbp1.RB}

Also Known As

UAS-Xbp1-RB, UAS-Xbp1s, UAS::xbp1^spliced, xbp1-RB

Key Links

Transgenic product class

wild_type

(Ryoo et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ryoo et al., 2007)

Mutagen

in vitro construct

(Ryoo et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Xbp1.RB}

Cytology

Description

UASt regulatory sequences drive expression of theXbp1-RB isoform.

(Ryoo et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Xbp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number |adult stage |somatic clone, withScer\GAL4^unspecified

(Wang et al., 2014)

increased cell death, withScer\GAL4^GMR.PF

(Ryoo et al., 2007)

increased cell death, withScer\GAL4^ninaE.PT

(Ryoo et al., 2007)

increased cell growth rate |second instar larval stage |conditional, withScer\GAL4^19-12,Scer\GAL80^repo.PL

(Song et al., 2015)

increased cell growth rate |second instar larval stage |conditional, withScer\GAL4^ppk.PU

(Song et al., 2015)

long lived, withScer\GAL4^bun-GSG5961

(Wang et al., 2015)

long lived, withScer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Phenotype Manifest In

autophagic vacuole & larval fat body | somatic clone | cell autonomous, withScer\GAL4^Act5C.PP

(Arsham and Neufeld, 2009)

eye, withScer\GAL4^GMR.PF

(Ryoo et al., 2007)

eye photoreceptor cell, withScer\GAL4^ninaE.PT

(Ryoo et al., 2007)

lysosome & larval fat body | somatic clone | cell autonomous, withScer\GAL4^Act5C.PP

(Arsham and Neufeld, 2009)

midgut |adult stage |somatic clone, withScer\GAL4^unspecified

(Wang et al., 2014)

secondary tracheal branch, withScer\GAL4^bs.Term

(Ríos-Barrera et al., 2017)

tracheal section, withScer\GAL4^bs.Term

(Ríos-Barrera et al., 2017)

Detailed Description

Statement

Reference

Expression ofXbp1^UAS.RB under the control ofScer\GAL4^bs.Term causes air-filling defects and reduced branch numbers in the trachea terminal cells region.

(Ríos-Barrera et al., 2017)

Overexpression ofXbp1^Scer\UAS.RB in class IV da neurons (Scer\GAL4^ppk.PU) or class III da neurons (Scer\GAL4^19-12 in combination withScer\GAL80^repo.PL) significantly enhances axon regeneration.

(Song et al., 2015)

Expression ofXbp1^Scer\UAS.RB under the control ofScer\GAL4^bun-GSG5961, using RU486 food supplementation to induce the expression, extends adult lifespan relative to controls.

(Wang et al., 2015)

The temporally regulated expression (by Gal80[ts]) ofXbp1^UAS.RB, for 5 days under the control ofScer\GAL4^NP5130, does not lead to a significant change in the proportion of mitotic cells in the adult midgut, as compared to controls; clonal expression under the control ofScer\GAL4^unspecified in adult midgut clones leads to a significant decrease in clone cell number at 7 days after clone induction, as compared to control clones.

(Wang et al., 2014)

Xbp1^Scer\UAS.RB clones in fat bodies from well-fed early third instar larvae (generated usingScer\GAL4^Act5C.PP) accumulate lysosomes, as indicated by elevated LysoTracker staining, and show redistribution of theAtg8a product into autophagosomes.

(Arsham and Neufeld, 2009)

Expression ofXbp1^Scer\UAS.RB under the control ofScer\GAL4^GMR.PF generates small, rough eyes with enhanced cell death.

(Ryoo et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^unspecified,Xbp1^UAS.RB hasdecreased cell number |somatic clone |adult stage phenotype, non-suppressible |somatic clone bycnc^VL110/cnc^VL110

(Wang et al., 2014)

Scer\GAL4^GMR.PF,Xbp1^UAS.RB hasincreased cell death phenotype, non-suppressible byBacA\p35^UAS.cHa,Scer\GAL4^GMR.PF

(Ryoo et al., 2007)

Suppressor of

Statement

Reference

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofincreased occurrence of cell division |adult stage phenotype ofEro1L^GD3577,Scer\GAL4^NP5130

(Wang et al., 2015)

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofincreased cell number |adult stage phenotype ofN^RNAi.P.UAS,Scer\GAL4^NP5130

(Wang et al., 2014)

Scer\GAL4^arm.PS/Xbp1^UAS.RB is a suppressor |partially ofneurogenic phenotype |maternal effect |embryonic stage phenotype ofpcx³

(Yamakawa et al., 2012)

Other

Statement

Reference

Scer\GAL4^unspecified,Xbp1^UAS.RB,cnc^VL110 hasdecreased cell number |somatic clone |adult stage phenotype

(Wang et al., 2014)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^unspecified,Xbp1^UAS.RB hasmidgut |somatic clone |adult stage phenotype, non-suppressible |somatic clone bycnc^VL110/cnc^VL110

(Wang et al., 2014)

Scer\GAL4^GMR.PF,Xbp1^UAS.RB haseye phenotype, non-suppressible byBacA\p35^UAS.cHa,Scer\GAL4^GMR.PF

(Ryoo et al., 2007)

Suppressor of

Statement

Reference

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofintestinal stem cell |adult stage phenotype ofEro1L^GD3577,Scer\GAL4^NP5130

(Wang et al., 2015)

Xbp1^UAS.RB/Scer\GAL4^NP5130 is a suppressor ofmidgut |adult stage phenotype ofScer\GAL4^NP5130,hep^UAS.cBa

(Wang et al., 2014)

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofintestinal stem cell |adult stage phenotype ofN^RNAi.P.UAS,Scer\GAL4^NP5130

(Wang et al., 2014)

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofenteroendocrine cell |adult stage phenotype ofN^RNAi.P.UAS,Scer\GAL4^NP5130

(Wang et al., 2014)

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor ofmidgut |adult stage phenotype ofN^RNAi.P.UAS,Scer\GAL4^NP5130

(Wang et al., 2014)

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a suppressor |partially ofmidgut |adult stage phenotype ofInR^UAS.cUa,Scer\GAL4^NP5130

(Wang et al., 2014)

Scer\GAL4^arm.PS/Xbp1^UAS.RB is a suppressor ofendoplasmic reticulum |maternal effect phenotype ofpcx³

(Yamakawa et al., 2012)

NOT Suppressor of

Statement

Reference

Xbp1^UAS.RB,Scer\GAL4^NP5130 is a non-suppressor ofmidgut |adult stage phenotype ofPrx2^RNAi.UAS.cUa,Scer\GAL4^NP5130

(Wang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The increased cell proliferation in the adult gut observed in flies expressingEro1L^GD3577 under the control ofScer\GAL4^esg-NP5130 (and using tub-Gal80[ts] to limit the time of expression) is suppressed by co-expression ofXbp1^Scer\UAS.RB.

(Wang et al., 2015)

Expression ofXbp1^Scer\UAS.RB under the control ofScer\GAL4^arm.PS inpcx³ embryos which lack maternal and zygoticpcx function partially rescues the neurogenic phenotype: 31% of embryos are fully rescued, 43% are partially rescued and 26% are not rescued. The endoplasmic reticulum defects are also rescued in 74% of cases.

(Yamakawa et al., 2012)

Xenogenetic Interactions

Statement

Reference

Co-expression ofBacA\p35^Scer\UAS.cHa does not suppress the small, rough eyes with enhanced cell death phenotype ofXbp1^Scer\UAS.RB,Scer\GAL4^GMR.PF flies.

(Ryoo et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Xbp1^Scer\UAS.RB

Xbp1^UAS.RB

Name Synonyms

Secondary FlyBase IDs

References (14)

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