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General Information

Symbol

Dmel\Egfr^Act.cUa.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0219093

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{UAS-Egfr.Act.U}

Also Known As

UAS-EGFR^CA, UAS-Egfr^Act

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Egfr.Act.U}

Cytology

Description

UAS regulatory sequences drive expression of activatedEgfr.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of high grade glioma

CEA withPi3K92E^CAAX.UAS

(Pryszlak et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

denticle |ectopic, withScer\GAL4^sca.PU

(Overton et al., 2007)

Detailed Description

Statement

Reference

Larvae expressingEgfr^{Act.cUa.Scer\UAS} under the control ofScer\GAL4^sca.PU results in the formation of three to 4 rows of ectopic denticles posterior to the wild-type row 6 denticles.

(Overton et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Egfr^Act.cUa.UAS,Scer\GAL4^sca.PU hasdenticle |ectopic phenotype, suppressible bySoxN^GA1192

(Overton et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic denticle formation seen in larvae expressingEgfr^{Act.cUa.Scer\UAS} under the control ofScer\GAL4^sca.PU is strongly reduced bySoxN^GA1192.

(Overton et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Egfr^{Act.cUa.Scer\UAS}

Egfr^Act.cUa.UAS

Egfr^CA

(Zhao et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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