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General Information

Symbol

Dmel\Drep2^GD9693

Species

D. melanogaster

Name

FlyBase ID

FBal0208257

Feature type

allele

Associated gene

Dmel\Drep2

Associated Insertion(s)

Carried in Construct

P{GD9693}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9693}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9693

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy |larval stage, withScer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

abnormal starvation stress response |adult stage, withScer\GAL4^NP0001

(Havula et al., 2022)

lethal, withScer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

lethal - all die before end of larval stage, withScer\GAL4^Cg.PU

(Havula et al., 2022)

lethal - all die before end of larval stage, withScer\GAL4^Mef2.PU

(Havula et al., 2022)

lethal - all die during larval stage, withScer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

majority die during larval stage |nutrition conditional, withScer\GAL4^Ubi.PU

(Havula et al., 2022)

partially lethal - majority die, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority die |nutrition conditional, withScer\GAL4^Ubi.PU

(Havula et al., 2022)

short lived |calorie restriction conditional, withScer\GAL4^NP0001

(Havula et al., 2022)

some die during pupal stage, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, withDcr-2^UAS.cDa,Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, withScer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

ganglion mother cell |larval stage, withScer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast |larval stage, withScer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mesonotum, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

sarcomere, withScer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

Z disc, withScer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

Detailed Description

Statement

Reference

Expression under the control ofScer\GAL4¹⁴⁰⁷ results in an increase in the average size of neuroblasts in the larval brain compared to controls.

Expression under the control ofScer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control ofScer\GAL4¹⁴⁰⁷ results in mild defects in the shape of neuroblasts in the larval brain.

Expression under the control ofScer\GAL4¹⁴⁰⁷ results in an increase in the average size of ganglion mother cells in the larval brain compared to controls.

(Neumüller et al., 2011)

Adults expressingDrep2^GD9693 under the control ofScer\GAL4^elav.PLu (in the presence ofDcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control ofScer\GAL4^Mef2.PR results in late larval lethality.

Expression under the control ofScer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control ofScer\GAL4^Mef2.PR results in sarcomeres with reduced Z-lines in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control ofScer\GAL4^pnr-MD237 results in the absence of 100% of theScer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9693

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v20771

w¹¹¹⁸; P{GD9693}v20771

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 2 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9693

Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells

9693

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Drep-2^GD9693

Drep2^GD9693

Rep2^GD9693

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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