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General Information

Symbol

Dmel\Jra^GD4400

Species

D. melanogaster

Name

FlyBase ID

FBal0207427

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

P{GD4400}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4400}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4400

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority die, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority live, withScer\GAL4^Tub.PU

(Havula et al., 2022)

some die during pupal stage, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, withDcr-2^UAS.cDa,Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, withScer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

adult heart |RU486 conditional, withScer\GAL4^{Hand.ΔVM.Switch}

(Monnier et al., 2012)

mesonotum, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression ofJra^GD4400 under the control ofScer\GAL4^{Hand.ΔVM.Switch} (initiated by feeding flies RU486 during adulthood) results in improved cardiac function compared to controls. Heart period (mean time between successive end-diastolic positions) and frequency of arrhythmicity are reduced at 45 days compared to age-matched controls. Expression ofJra^GD4400 also prevents the age-related decrease in End-Diastolic Diameter (EDD) seen in wild type flies.

(Monnier et al., 2012)

Adults expressingJra^GD4400 under the control ofScer\GAL4^elav.PLu (in the presence ofDcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control ofScer\GAL4^pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 80-90% of theScer\GAL4^pnr-MD237 expression domain.

Expression under the control ofScer\GAL4^pnr-MD237 results in strong thorax closure defects.

Expression under the control ofScer\GAL4^pnr-MD237 results in an enlarged notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4400

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v10835

w¹¹¹⁸ P{GD4400}v10835

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4400

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Jra^GD4400

(Havula et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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