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General Information

Symbol

Dmel\galene^GD2237

Species

D. melanogaster

Name

FlyBase ID

FBal0206137

Feature type

allele

Associated gene

Dmel\galene

Associated Insertion(s)

Carried in Construct

P{GD2237}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2237}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2237

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, withDcr-2^UAS.cDa,Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, withScer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, withScer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

chaeta |increased number, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

mesonotum, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

trichogen cell |increased number, withScer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Adults expressingCG9194^GD2237 under the control ofScer\GAL4^elav.PLu (in the presence ofDcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control ofScer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control ofScer\GAL4^pnr-MD237 results in extra bristles on the notum in 30-40% of theScer\GAL4^pnr-MD237 expression domain.

Expression under the control ofScer\GAL4^pnr-MD237 results in duplication of bristle hairs on the notum in 0% or 10-20% of theScer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control ofScer\GAL4^pnr-MD237 results in the absence of 0% or 60-70% of theScer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

Expression under the control ofScer\GAL4^pnr-MD237 may result in mild thorax closure defects, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2237

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v40837

w¹¹¹⁸; P{GD2237}v40837

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2237

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9194^GD2237

galene^GD2237

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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