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General Information

Symbol

Dmel\hep^r39

Species

D. melanogaster

Name

FlyBase ID

FBal0045849

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Glise et al., 1995)

Mutagen

PM hybrid dysgenesis

(Glise et al., 1995)

Progenitor genotype

hep¹

(Glise et al., 1995)

Cytology

Description

Excision of theP-element insertion.

(Glise et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy |somatic clone

(Rallis et al., 2010)

lethal |recessive

(Agnes et al., 1999,Holland et al., 1997)

visible (withhep¹)

(Agnes et al., 1999)

Phenotype Manifest In

adult thorax (withhep¹)

(Agnes et al., 1999)

axon |somatic clone

(Rallis et al., 2010)

chaeta (withhep¹)

(Agnes et al., 1999)

imaginal disc

(Agnes et al., 1999)

Kenyon cell |somatic clone

(Rallis et al., 2010)

wing disc

(Agnes et al., 1999)

Detailed Description

Statement

Reference

hep^r39 neuroblast clones in mushroom bodies show axonal degeneration, though the main observable phenotype is overextension of axons.

(Rallis et al., 2010)

Discs dissected from L3 larvae are delayed in their development, reduced in size, and malformed or misfolded. Dissected pupae reveal one consistent and major defect: the absence or aberrant spreading and fusion of the two lateral wing discs. In some cases eversion does take place, in the absence of disc fusion. In viablehep^r39/hep^r75 transheterozygotes wing disc morphogenesis can proceed almost normally, with occasional unilateral defects.hep^r39/hep¹ adult females show mutant cleft thorax and bristle defects.

(Agnes et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hep^r39/hep¹ hasvisible phenotype, suppressible bypuc^E69

(Agnes et al., 1999)

NOT suppressed by

Statement

Reference

hep^r39 hasabnormal neuroanatomy |somatic clone phenotype, non-suppressible byScer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

hep^r39 haslethal phenotype, non-suppressible byMmus\Map2k7^Ubi-p63E.PH

(Holland et al., 1997)

hep^r39 haslethal phenotype, non-suppressible byXlae\Mek2^Ubi-p63E.PH

(Holland et al., 1997)

hep^r39 haslethal phenotype, non-suppressible byMmmm\Sek1^Ubi-p63E.PH

(Holland et al., 1997)

Other

Statement

Reference

Mkk4^e01485,hep^r39 hasabnormal neuroanatomy |somatic clone |adult stage phenotype

(Rallis et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

hep^r39 haswing disc phenotype, suppressible bypuc^E69

(Agnes et al., 1999)

hep^r39/hep¹ hasadult thorax phenotype, suppressible bypuc^E69

(Agnes et al., 1999)

hep^r39/hep¹ haschaeta phenotype, suppressible bypuc^E69

(Agnes et al., 1999)

hep^r39 hasimaginal disc phenotype, suppressible bypuc^E69

(Agnes et al., 1999)

NOT suppressed by

Statement

Reference

hep^r39 hasKenyon cell |somatic clone phenotype, non-suppressible byScer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

hep^r39 hasaxon |somatic clone phenotype, non-suppressible byScer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

Other

Statement

Reference

Mkk4^e01485,hep^r39 hasalpha/beta Kenyon cell |somatic clone phenotype

(Rallis et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

28 day old flies containinghep^r39 Mkk4^e01485 double mutant neuroblast clones exhibit β-axon loss in the mushroom body.

(Rallis et al., 2013)

The axon degeneration and overextension phenotypes ofhep^r39 neuroblast clones in mushroom bodies is not suppressed by expression ofMkk4^{Scer\UAS.T:Avic\GFP-YFP} usingScer\GAL4^ey-OK107.

(Rallis et al., 2010)

Double mutants withpuc^E69/+ show discs of uniform size intermediate between those of wild type and unsuppressedhep single mutants. In combination withpuc^E69 thehep^r39/hep¹ adult defects are strongly reduced.

(Agnes et al., 1999)

Xenogenetic Interactions

Statement

Reference

The lethality of hemizygous males is not significantly rescued byMmus\Prkmk7^Ubi-p63E.PH,Xlae\Mek2^Ubi-p63E.PH orMmmm\Sek1^Ubi-p63E.PH.

(Holland et al., 1997)

Complementation and Rescue Data

Rescued by

hep^r39 is rescued byhep^UAS.cBa/Scer\GAL4^ey-OK107

(Rallis et al., 2010)

Comments

Expression ofhep^Scer\UAS.cBa withScer\GAL4^ey-OK107 rescues the axonal phenotypes seen inhep^r39 mushroom body clones.

(Rallis et al., 2010)

The lethality of hemizygous males is rescued byhep^Ubi-p63E.PG, giving rise to viable, fertile adults in 48% of cases.

(Holland et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hep^R39

(Rallis et al., 2013,Rallis et al., 2010)

hep^r39

Name Synonyms

Secondary FlyBase IDs

References (5)

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