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General Information

Symbol

Dmel\in^IH56

Species

D. melanogaster

Name

FlyBase ID

FBal0039446

Feature type

allele

Associated gene

Dmel\in

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Adler et al., 1994)

Mutagen

ethyl methanesulfonate

(Adler et al., 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Lu et al., 2010)

abnormal planar polarity |adult stage

(Wang et al., 2017)

abnormal planar polarity |cell autonomous |somatic clone

(Lee and Adler, 2002)

visible |adult stage

(Wang et al., 2017)

visible |cold sensitive

(Adler et al., 1994)

Phenotype Manifest In

abdominal sternite bristle

(Wang et al., 2017)

macrochaeta |cold sensitive

(Adler et al., 1994)

microchaeta & wing

(Park et al., 1996)

wing hair

(Wang et al., 2017,Lu et al., 2010)

wing hair |cell autonomous |somatic clone

(Lee and Adler, 2002)

wing hair |increased number

(Lu et al., 2010)

Detailed Description

Statement

Reference

in^IH56 mutant adults display multiple hair cell phenotype and hair polarity defects in both wing hairs and abdominal bristles.

(Wang et al., 2017)

Hairs in the proximal-anterior part of the wing point towards the anterior margin and most cells form multiple hairs in mutant adults.

(Lu et al., 2010)

Mutant clones in the wing show disruption of polarity, as indicated by wing hairs.

(Lee and Adler, 2002)

Unmarked clones in all regions of the wing display anin phenotype, cells form more than one hair and hairs with an abnormal polarity. Marked clones in the wing indicatein acts autonomously, cells bordering clones are wild type.P{in⁺12} construct can completely rescue the wing hair phenotype. Heat induced expression ofP{hs-in} can provide nearly complete rescue of the wing hair phenotype, some multiple hairs are still present. Rescue of thein^IH56 mutant phenotype byP{hs-in(RGE)} is indistinguishable from rescue byP{hs-in}.

(Park et al., 1996)

Viable as a homozygote or a hemizygote. Strong thoracic bristle and wing hair phenotype. Percentage of dorsal wing surface cells that display abnormal cell polarity and the percentage of wing cells forming more than one hair is more severe at 18^oC than 29^oC.

(Adler et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

in^IH56 hasvisible |adult stage phenotype, non-enhanceable byds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 hasabnormal planar polarity |adult stage phenotype, non-enhanceable byds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 hasvisible |adult stage phenotype, non-enhanceable byfy²/fy²

(Wang et al., 2017)

in^IH56 hasabnormal planar polarity |adult stage phenotype, non-enhanceable byfy²/fy²

(Wang et al., 2017)

in^IH56 hasvisible |adult stage phenotype, non-enhanceable byfrtz³⁰/frtz³⁰

(Wang et al., 2017)

in^IH56 hasabnormal planar polarity |adult stage phenotype, non-enhanceable byfrtz³⁰/frtz³⁰

(Wang et al., 2017)

Suppressed by

Statement

Reference

in^IH56 hasvisible |adult stage phenotype, suppressible byfrtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56 hasabnormal planar polarity |adult stage phenotype, suppressible byfrtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56,mwh¹ hasabnormal planar polarity phenotype, suppressible |partially byin::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

in^IH56 hasabnormal planar polarity phenotype, suppressible byScer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

NOT Enhancer of

Statement

Reference

in^IH56/in^IH56 is a non-enhancer ofvisible |adult stage phenotype offrtz³⁰

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer ofabnormal planar polarity |adult stage phenotype offrtz³⁰

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer ofvisible |adult stage phenotype offy²

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer ofabnormal planar polarity |adult stage phenotype offy²

(Wang et al., 2017)

Suppressor of

Statement

Reference

in^IH56/in^unspecified is a suppressor ofabnormal planar polarity |somatic clone |cell non-autonomous phenotype offz²¹

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in^IH56/in^unspecified is a non-suppressor ofabnormal planar polarity |somatic clone |cell autonomous phenotype offz²¹

(Lee and Adler, 2002)

in^IH56 is a non-suppressor ofabnormal planar polarity |somatic clone |cell non-autonomous phenotype offz²¹

(Lee and Adler, 2002)

Other

Statement

Reference

Scer\GAL4^ptc-559.1,dsh^UAS.cAa,in^IH56 hasabnormal planar polarity phenotype

(Lee and Adler, 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

in^IH56 hasabdominal sternite bristle phenotype, non-enhanceable byds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 hasabdominal sternite bristle phenotype, non-enhanceable byfy²/fy²

(Wang et al., 2017)

in^IH56 hasabdominal sternite bristle phenotype, non-enhanceable byfrtz³⁰/frtz³⁰

(Wang et al., 2017)

Suppressed by

Statement

Reference

in^IH56 haswing hair phenotype, suppressible byfrtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56 haswing hair phenotype, suppressible byScer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

in^IH56 haswing hair |increased number phenotype, suppressible byScer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

in^IH56,mwh¹ haswing hair phenotype, suppressible |partially byin::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

in^IH56,mwh¹ haswing hair |increased number phenotype, suppressible |partially byin::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

NOT Enhancer of

Statement

Reference

in^IH56/in^IH56 is a non-enhancer ofabdominal sternite bristle phenotype offy²

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer ofabdominal sternite bristle phenotype offrtz³⁰

(Wang et al., 2017)

Suppressor of

Statement

Reference

in^IH56/in^unspecified is a suppressor ofwing hair |somatic clone |cell non-autonomous phenotype offz²¹

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in^IH56/in^unspecified is a non-suppressor ofwing hair |somatic clone |cell autonomous phenotype offz²¹

(Lee and Adler, 2002)

in^IH56 is a non-suppressor ofwing hair |somatic clone |cell non-autonomous phenotype offz²¹

(Lee and Adler, 2002)

Other

Statement

Reference

Scer\GAL4^ptc-559.1,dsh^UAS.cAa,in^IH56 hasmacrochaeta phenotype

(Lee and Adler, 2002)

Scer\GAL4^ptc-559.1,dsh^UAS.cAa,in^IH56 has wing hair & 1st posterior cell phenotype

(Lee and Adler, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The multiple hair cell and abnormal hair polarity phenotypes observed inin^IH56 mutant flies are strongly suppressed by expression offrtz^{Scer\UAS.WALIUM.T:Hsap\MYC} under the control ofScer\GAL4^Act.PU in the mutant background.

in^IH56;ds^YAC41/ds^UAO71 double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as inin^IH56 single mutants andfy²/in^IH56 as well asfrtz³⁰/in^IH56 double mutants show bristle phenotype that is comparable to each of the single mutants.

(Wang et al., 2017)

The wing hair phenotype ofin^IH56 mwh¹ double mutants is indistinguishable from that ofmwh¹ single mutants.

Expression ofin::mwh^Scer\UAS.cLa under the control ofScer\GAL4^Act.PU essentially completely rescues the wing hair defects ofin^IH56 mutants.

Expression ofin::mwh^Scer\UAS.cLa under the control ofScer\GAL4^ap-md544 strongly rescues the wing hair defects ofin^IH56 mwh¹ double mutants on the dorsal surface of the wing.

(Lu et al., 2010)

The multiple hair cell phenotype ofdsh^Scer\UAS.cAa expressed fromScer\GAL4^ptc-559.1 is additive with the multiple hair phenotypes offy² andin^IH56. When a wing clone is doubly mutant forfz²¹ andin^IH56, domineering nonautonomy of polarity defect offz²¹ is unaffected. When a wing clone is doubly mutant forfz²¹ andin^IH56 in a genetic background deficient forin, domineering nonautonomy of polarity defect offz²¹ is suppressed, though polarity defect within the clone is not.

(Lee and Adler, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strongin allele.

(Adler et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

in^IH56

(Wang et al., 2017,Lu et al., 2010,Strutt and Warrington, 2008)

Name Synonyms

Secondary FlyBase IDs

References (10)

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