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General Information

Symbol

Dmel\Egfr^flb-2E07

Species

D. melanogaster

Name

FlyBase ID

FBal0033661

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

flb^2E07, egfr^2E07, flb^2EO7

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Stemerdink and Jacobs, 1997,Clifford and Schupbach, 1989)

Mutagen

ethyl methanesulfonate

(Clifford and Schupbach, 1989,Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ /EMBL /GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage |recessive

(Clifford and Schupbach, 1989)

some die during embryonic stage |recessive

(Clifford and Schupbach, 1989)

Phenotype Manifest In

dorsal appendage

(Ghiglione et al., 1999)

egg

(Ghiglione et al., 1999)

eye (withEgfr^t1)

(Alvarado et al., 2004)

midline glial cell

(Stemerdink and Jacobs, 1997)

Detailed Description

Statement

Reference

Egfr^t1/Egfr^flb-2E07 animals have rough eyes.

(Alvarado et al., 2004)

Eggs derived fromEgfr^t1/Egfr^flb-2E07 females are ventralised and have no or only one dorsal appendage.

(Ghiglione et al., 1999)

Homozygous embryos lack all midline glia cells.

(Stemerdink and Jacobs, 1997)

Homozygotes display a weak 'flb' phenotype and hemizygotes display an intermediate 'flb' phenotype. Embryos produced from heteroallelic combination withEgfr^t1 have a severe ventralised phenotype, reduction in size of their dorsal appendage.

(Clifford and Schupbach, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Egfr^flb-2E07 has phenotype, non-enhanceable byrho^hs.PSt

(Lanoue and Jacobs, 1999)

Suppressed by

Statement

Reference

Egfr^flb-2E07/Egfr^t1 haseye phenotype, suppressible bykek1^RA5/kek1^RM2

(Alvarado et al., 2004)

Egfr^flb-2E07/Egfr^t1 haseye phenotype, suppressible |partially bykek1^RA5/kek1[+]

(Alvarado et al., 2004)

Egfr^flb-2E07/Egfr^t1 haseye phenotype, suppressible |partially by kek1[+]/kek1^RM2

(Alvarado et al., 2004)

Egfr^flb-2E07/Egfr^t1 hasegg phenotype, suppressible |partially bykek1^RA5/kek1^RM2

(Ghiglione et al., 1999)

Egfr^flb-2E07/Egfr^t1 hasdorsal appendage phenotype, suppressible |partially bykek1^RA5/kek1^RM2

(Ghiglione et al., 1999)

NOT suppressed by

Statement

Reference

Egfr^flb-2E07 has phenotype, non-suppressible byrho^hs.PSt

(Lanoue and Jacobs, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygouskek1^RM2 orkek1^RA5 partially suppresses the rough eye phenotype seenEgfr^flb-2E07/Egfr^t1 animals.kek1^RM2/kek1^RA5 fully suppresses the phenotype.

(Alvarado et al., 2004)

TheEgfr^t1/Egfr^flb-2E07 phenotype is partially suppressed bykek1^RA5/kek1^RM2.

(Ghiglione et al., 1999)

The ubiquitous expression ofrho^hs.PSt under heatshock has no effect onEgfr^flb-2E07 embryos.

(Lanoue and Jacobs, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation ofEgfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions:Egfr^t2 =Egfr^t1 <Egfr^top-EC20 <Egfr^f7 =Egfr^f1 =Egfr^flb-2E07 <Egfr^top-EE39 =Egfr^top-ED26 =Egfr^f5 <Egfr^f9 =Egfr^f10 =Egfr^f2 =Egfr^top-EE42 =Egfr^f11 =Egfr^f24 =Egfr^f3 =Df(2R)Egfr3.

(Clifford and Schupbach, 1989)

WeakEgfr allele.

(Raz and Shilo, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Egfr^flb-2E07

Egfr^top-2E07

egfr^2E07

(Alvarado et al., 2004,Ghiglione et al., 1999)

flb^2E07

(Lanoue and Jacobs, 1999,Stemerdink and Jacobs, 1997,Schweitzer et al., 1995)

flb^2EO7

(Raz and Shilo, 1993,Raz et al., 1991)

flb^IIE07

(Stemerdink and Jacobs, 1997)

flb^IIE

(Tearle and Nusslein-Volhard, 1987)

top^2E07

(Clifford and Schupbach, 1989)

Name Synonyms

Secondary FlyBase IDs

FBal0033664

References (9)

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