The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves ofPiper betle L.
A new ether derivative of phenylpropanoid compound,γ-(γ′-isohydroxychavicol)-chavicol octanyl ether (K1) along with one known phenylpropanoid namedallyl-pyrocatechol or hydroxychavicol (2) were isolated fromPiper betle var.kali collected from Tumluk district, West Bengal India. We first report the presence of compoundK1 in the genusPiper. Their structures were established on the basis of various spectroscopic analyses. CompoundsK1 and2 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 4.61 and 4.12 µg/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 3.42 µg/mL, respectively. Evaluation ofin vitro cytotoxic activities of compoundsK1 and2 showed significant effects against human oral cancer cell lines (AW13516 and AW8507), human hepatoma cell lines (HEPG2 and PLC-PRF-5) and a human pancreatic cell line (MIA-PA-CA-2), compared to Doxorubicin® as a standard cytotoxic drug with GI50 values of<10 and 18.18 µg/mL.
