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ویکی‌پدیادانشنامهٔ آزاد
جستجو

POU2F1

از ویکی‌پدیا، دانشنامهٔ آزاد
POU2F1
ساختارهای موجود
PDBجستجوی هم‌ساخت‌شناسی:PDBeRCSB
فهرست شناسه‌های PDB

1CQT,1E3O,1GT0,1HF0,1O4X,1OCT,1POG

معین‌کننده‌ها
نام‌های دیگرPOU2F1, OCT1, OTF1, oct-1B, POU class 2 homeobox 1, Oct1Z
شناسه‌های بیرونیOMIM:164175MGI:101898HomoloGene:37658GeneCards:POU2F1
موقعیت ژن (موش)
کروموزوم ۱ (موش)
کروموزومکروموزوم ۱ (موش)[۱]
کروموزوم ۱ (موش)
موقعیت ژنومی POU2F1
موقعیت ژنومی POU2F1
نوار1 H2.3|1 73.21 cMشروع165,692,723bp[۱]
پایان165,830,247bp[۱]
الگویگسترش RNA
More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی•sequence-specific DNA binding
•GO:0001948، GO:0016582 پیوند پروتئینی
•RNA polymerase II core promoter sequence-specific DNA binding
•GO:0000983 RNA polymerase II general transcription initiation factor activity
•DNA binding
•GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity
•GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
•GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
ترکیبات سلولی•شبکه آندوپلاسمی
•هسته یاخته
•intracellular membrane-bounded organelle
•نوکلئوپلاسم
•RNA polymerase II transcription regulator complex
فرایند زیستی•GO:0045996 negative regulation of transcription, DNA-templated
•GO:0009373 regulation of transcription, DNA-templated
•transcription, DNA-templated
•snRNA transcription by RNA polymerase II
•GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II
•cytokine-mediated signaling pathway
منابع:آمیگو /کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

5451

18986

آنسامبل

ENSG00000143190

ENSMUSG00000026565

یونی‌پروت

P14859

P25425

RefSeq (mRNA)

NM_001198783، NM_001198786، NM_002697، NR_037163، XM_011509653، XM_011509654، XM_017001508، NM_001365848، NM_001365849، XM_047422869، XM_047422875، XM_047422877 XM_011509655، NM_001198783، NM_001198786، NM_002697، NR_037163، XM_011509653، XM_011509654، XM_017001508، NM_001365848، NM_001365849، XM_047422869، XM_047422875، XM_047422877

NM_198932، NM_198933، NM_198934، XM_006496704، XR_373598، XM_017319360، NM_001368808، XM_030252286، XM_030252287، XM_036162785 NM_011137، NM_198932، NM_198933، NM_198934، XM_006496704، XR_373598، XM_017319360، NM_001368808، XM_030252286، XM_030252287، XM_036162785

RefSeq (پروتئین)

NP_001185715، NP_002688، XP_011507955، XP_011507956، XP_011507957، XP_016856997، XP_024303495، NP_001352777، NP_001352778 NP_001185712، NP_001185715، NP_002688، XP_011507955، XP_011507956، XP_011507957، XP_016856997، XP_024303495، NP_001352777، NP_001352778

NP_945150، NP_945151، NP_945152، XP_006496767، XP_017174849، NP_001355737، XP_030108146، XP_030108147، XP_036018678 NP_035267، NP_945150، NP_945151، NP_945152، XP_006496767، XP_017174849، NP_001355737، XP_030108146، XP_030108147، XP_036018678

موقعیت (UCSC)ن/مChr : 165.69 – 165.83 Mb
جستجویPubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

دامنه POU، کلاس ۲، فاکتور رونویسی ۱پروتئینی است که در انسان توسطژنPOU2F1 کدگذاری می شود.[۴][۵]

فعل و انفعالات

[ویرایش]

مشخص شده است که POU2F1 با پروتئین های زیر،تعامل پروتئین-پروتئین دارد:

منابع

[ویرایش]
  1. 123GRCm38: Ensembl release 89: ENSMUSG00000026565 -Ensembl, May 2017
  2. ↑"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑Roberts SB, Segil N, Heintz N (October 1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle".Science.253 (5023): 1022–6.doi:10.1126/science.1887216.PMID 1887216.
  5. ↑"Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1".
  6. ↑Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (March 1998). "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase".FEBS Lett.424 (1–2): 27–32.doi:10.1016/s0014-5793(98)00131-8.PMID 9537509.S2CID 872132.
  7. 12Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ (September 1999)."Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter".J. Biol. Chem.274 (38): 26713–9.doi:10.1074/jbc.274.38.26713.PMID 10480874.
  8. ↑Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ (October 1999)."Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding".Mol. Cell. Biol.19 (10): 7106–22.doi:10.1128/mcb.19.10.7106.PMC 84705.PMID 10490647.
  9. ↑Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ (June 1998)."Recruitment of octamer transcription factors to DNA by glucocorticoid receptor".Mol. Cell. Biol.18 (6): 3416–30.doi:10.1128/mcb.18.6.3416.PMC 108923.PMID 9584182.
  10. 12McKnight S (July 2003)."Gene switching by metabolic enzymes--how did you get on the invitation list?".Cell.114 (2): 150–2.doi:10.1016/s0092-8674(03)00563-4.PMID 12887915.S2CID 895360.
  11. ↑La Boissière S, Hughes T, O'Hare P (January 1999)."HCF-dependent nuclear import of VP16".EMBO J.18 (2): 480–9.doi:10.1093/emboj/18.2.480.PMC 1171141.PMID 9889203.
  12. ↑Kristie TM, Sharp PA (March 1993)."Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)".J. Biol. Chem.268 (9): 6525–34.doi:10.1016/S0021-9258(18)53282-8.PMID 8454622.
  13. ↑Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (May 2001)."The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase".J. Biol. Chem.276 (20): 16848–56.doi:10.1074/jbc.M100768200.PMID 11279128.
  14. ↑Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication".Biochim. Biophys. Acta.1578 (1–3): 59–72.doi:10.1016/s0167-4781(02)00497-9.PMID 12393188.
  15. ↑Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997)."The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors".J. Biol. Chem.272 (47): 29852–8.doi:10.1074/jbc.272.47.29852.PMID 9368058.
  16. ↑Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K (March 2001)."Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor".J. Biol. Chem.276 (13): 9720–5.doi:10.1074/jbc.M008531200.PMID 11134019.
  17. 12Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998)."The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1".Mol. Cell. Biol.18 (1): 368–77.doi:10.1128/mcb.18.1.368.PMC 121507.PMID 9418884.
  18. ↑Chasman D, Cepek K, Sharp PA, Pabo CO (October 1999)."Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface".Genes Dev.13 (20): 2650–7.doi:10.1101/gad.13.20.2650.PMC 317104.PMID 10541551.
  19. ↑Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (June 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator".Biochemistry.40 (22): 6580–8.doi:10.1021/bi010095x.PMID 11380252.
  20. ↑van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D (May 2002)."Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors".Hum. Mol. Genet.11 (11): 1281–9.doi:10.1093/hmg/11.11.1281.PMID 12019209.
  21. ↑Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori Ji, Kumagai M, Hashizume K (July 1999)."Functional interaction between Oct-1 and retinoid X receptor".J. Biol. Chem.274 (27): 19103–8.doi:10.1074/jbc.274.27.19103.PMID 10383413.
  22. ↑Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex".Acta Crystallogr. D.58 (Pt 3): 511–2.doi:10.1107/s0907444901021461.PMID 11856838.
  23. ↑Ström AC, Forsberg M, Lillhager P, Westin G (June 1996)."The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression".Nucleic Acids Res.24 (11): 1981–6.doi:10.1093/nar/24.11.1981.PMC 145891.PMID 8668525.
  24. ↑Gunther M, Laithier M, Brison O (July 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening".Mol. Cell. Biochem.210 (1–2): 131–42.doi:10.1023/A:1007177623283.PMID 10976766.S2CID 1339642.
  25. ↑Zwilling S, Annweiler A, Wirth T (May 1994)."The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP".Nucleic Acids Res.22 (9): 1655–62.doi:10.1093/nar/22.9.1655.PMC 308045.PMID 8202368.

جهت مطالعه

[ویرایش]

پیوند به بیرون

[ویرایش]
برگرفته از «https://fa.wikipedia.org/w/index.php?title=POU2F1&oldid=42953787»
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