بیان ژن HK3 در سرطان فولیکولارتیروئید تشدید می‌شود و از آنزیم HK3، در کنارسایکلین A وگالکتین-۳ می‌توان به‌عنوان بیومارکر تشخیصی، جهت غربالگری بدخیمی در بیماران استفاده نمود.[۷][۸]
این ژن بالعکس در سلول‌های بلاست سرطانAML و همچنین لوسمی پرومیلوسیتیک حاد تضعیف می‌گردد. در سرطانALL نیز ثابت شده‌است که HK3 در کنارHK2 وHK1، خواص ضدآپوپتوزی دارد.[۷]
↑"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
↑"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
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