Movatterモバイル変換

Kaltzitonina

Wikipedia, Entziklopedia askea

Kaltzitonina

Egitura erabilgarria

Ortologoaren bilaketa:PDBe RCSB

PDB ID kodeen zerrenda
2JXZ,%%s1LS7

Identifikatzaileak

CALCA (HUGO), CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1

Kanpoko IDak

OMIM:114130 MGI:2151253 HomoloGene:88401 GeneCards:CALCA OMA:CALCA - orthologs

Drogaren xedea

Calcitonin receptor

Itzul dezakezu

^[1]

Genearen kokapena (gizakia)


Kromosoma:11 (gizakia)^[2]

Banda	11p15.2	Hasiera	14.966.668bp^[2]
Banda	11p15.2	Amaiera	14.972.351 bp^[2]

Genearen kokapena (sagua)


Kromosoma:7 (sagua)^[3]

Banda	7 F1\|7 59.99 cM	Hasiera	114.230.713bp^[3]
Banda	7 F1\|7 59.99 cM	Amaiera	114.235.592 bp^[3]

RNA adierazpen eredua

gizakia

sagua (ortholog)

Adierazpen ohikoena

spinal ganglia

trigeminal ganglion

koadrizeps muskulu femoral

vastus lateralis muscle

cerebellar vermis

Langerhansen irla

human kidney

Epithelium of choroid plexus

Atzeko muskulu tibial

right lobe of liver

Adierazpen ohikoena

Aurpegi nerbioaren nukleo

neurona motor

lumbar spinal ganglion

anterior horn of spinal cord

lactiferous gland

Trakea

trigeminal ganglion

enbrioi

enbrioi

vestibular membrane of cochlear duct

Erreferentziazko adierazpen datu gehiago


Erreferentziazko adierazpen datu gehiago

Gene ontologia
Funtzio molekularra	hormone activity calcitonin receptor binding proteina lotura identical protein binding signaling receptor binding protein-containing complex binding
Zelularen osagaia	zitoplasma intrazelular zelulaz kanpoko eremu Axoi terminal bouton soma neuron projection zelula nukleo extracellular space
Prozesu biologikoa	cellular response to nerve growth factor stimulus positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of smooth muscle contraction regulation of heart contraction monocyte chemotaxis negative regulation of blood pressure positive regulation of cytosolic calcium ion concentration cellular response to tumor necrosis factor giza zahartze basodilatazio zelulako kaltzio ioi homeostasia response to heat negative regulation of nervous system process positive regulation of ossification activation of adenylate cyclase activity regulation of heart rate detection of temperature stimulus involved in sensory perception of pain negative regulation of ossification response to pain artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure feeding behavior inflammatory response neuropeptide signaling pathway negative regulation of transcription, DNA-templated activation of protein kinase activity embryo implantation negative regulation of bone resorption regulation of signaling receptor activity G proteina errezeptore akoplatuaren komunikazio bidea adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cytosolic calcium ion concentration leukocyte cell-cell adhesion G protein-coupled receptor internalization positive regulation of interleukin-1 alpha production response to yeast negative regulation of osteoclast differentiation cell-cell signaling antibacterial humoral response positive regulation of macrophage differentiation receptor internalization regulation of blood pressure protein phosphorylation vasculature development defense response to Gram-negative bacterium endothelial cell proliferation positive regulation of interleukin-8 production nervous system process involved in regulation of systemic arterial blood pressure negative regulation of calcium ion transport into cytosol berezko sistema immune endothelial cell migration antifungal humoral response defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide amylin receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway
Iturburuak: :Amigo /QuickGO

Ortologoak

Espeziea

Gizakia

Sagua


796


12310


ENSG00000110680


ENSMUSG00000030669


P06881


P70160 Q99JA0

RefSeq (RNAm)


NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950


NM_001033954 NM_007587 NM_001289444 NM_001305616

RefSeq (proteina)


NP_001029125.1


NP_001029126 NP_001276373 NP_001292545 NP_031613 NP_001029126.1 NP_001276373.1

Kokapena (UCSC)

Chr 11: 14.97 – 14.97 Mb

Chr 7: 114.23 – 114.24 Mb

PubMed bilaketa

^[4]

^[5]

Ikusi/Editatu giza genea

Ikusi/Editatu saguaren genea

Kaltzitoninatiroide guruinaren zelula parafolikularrek sintetizatzen dutenhormona da. Hormona honekodoleko kaltzio etafosfato kontzentrazioak murrizten ditu.

Odolean kaltzio kontzentrazioaren igoera bat ematen denean tiroidea aktibatu egiten da eta kaltzitonina jariatzen hasten da. Kaltzitoninak efektu fisiologiko desberdinak izango ditu:

Giltzurrunean kaltzio eta fosfatoaren birxurgapena gutxitzen du.
Hezurretan osteoklastoak inhibitu etaosteoblastoak aktibatzen ditu. Horren eraginez, hezurraren birxurgapena edo erreabsortzioa moteltzen da eta kaltzioa odoletik hezurretara pasatzen da.

Izokinaren kaltzitonina hainbatgaixotasunen tratamenduan erabili izan da:

Erreferentziak

[aldatu |aldatu iturburu kodea]

↑ Fisikoki elkarreragiten duten drogak Kaltzitoninaikusi/editatu erreferentziak Wikidatan..
↑^a ^b ^cGRCh38: Ensembl release 89: ENSG00000110680 -Ensembl, May 2017
↑^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030669 –Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

Kanpo estekak

[aldatu |aldatu iturburu kodea]

Autoritate kontrola

Wikimedia proiektuak
Datuak:Q315860
Multimedia:Calcitonin /Q315860

Identifikadoreak
BNE:XX531780
BNF:11964818b (data)
LCCN:sh85018767
NKC:ph214623
Medikuntzako identifikadoreak
FMA:83348
Kimikako identifikadoreak
CAS erregistro zenbakia:9007-12-9
ChEBI:3306
ChEMBL:CHEMBL1201614
ChemSpider:17288947
PubChem:16132288
UNII:DF35I47HCM
InChI key:ID
Biologiako identifikadoreak
MGI:9007-12-9

Datuak:Q315860
Multimedia:Calcitonin /Q315860

"https://eu.wikipedia.org/w/index.php?title=Kaltzitonina&oldid=9287984"(e)tik eskuratuta

Ezkutuko kategoriak:

[8]ページ先頭

©2009-2025 Movatter.jp