2012, Volker A Coenen, Jaak Panksepp, Trevor A Hurwitz, Horst Urbach, Burkhard Mädler, “Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression”, inThe Journal of Neuropsychiatry and Clinical Neurosciences,→DOI,→PMID:
Using Diffusion Tensor Imaging Fiber Tracking (DTI FT) the authors describe potential converging ascending and descending MFB and anteriorthalamic radiation (ATR) that may mediate major brain reward-seeking and punishment functions. Authors highlight novel connectivity, such as supero-lateral-branch MFB and ATR convergence, caudally as well as rostrally, in the anterior limb of the internal capsule and medial prefrontal cortex.
