Manganism has been known about since the 19th century, when miners exposed to ores containing manganese[…]began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death. Nowadays workers are exposed to far lowerdoses and manganism is rare.
“I had then, as you remember, just returned to London after a lot of Indian Ocean, Pacific, China Seas - a regulardose of the East - six years or so, and I was loafing about, hindering you fellows in your work and invading your homes, just as though I had got a heavenly mission to civilise you.”
2001, Susan Stryker,Queer Pulp, page78:
The prospect of becoming a father is adose of reality that threatens to bring his dream world crashing down.
1839, Benjamin Abbott,Experience and Gospel Labors of the Rev. Benjamin Abbott:
Just at the dawning of the day, I fell into adose more like sleep than any I had during the whole night, in which I dreamed that I saw a river as clear as crystal[…]
It was to me a marvellous experience; to be here, propped up with pillows in a dimly-lighted room, the night-nurse idlydosing by the fire; the sound of the everlasting wind in my ears, howling outside[…]