The Talas Region is a U-shaped valley open to the west. The northern border is defined by theKyrgyz Ala-Too, which also forms the Chuy Region's southern border. At the eastern end, theTalas Ala-Too Range splits off and marks the southern border. The riverTalas flows through the center of the valley.Kirov Reservoir is formed by damming the Talas river. The main highway (A361) enters from the east over the Ötmök Pass (Can become impassible during winter due to weather) and goes down the valley toTaraz in Kazakhstan. Near the valley's mouth atKyzyl-Adyr, one road goes north toward Taraz and the other south over theKara-Buura Pass to Jalal-Abad Province. Before independence most trade links were with Taraz.
The population of Talas Region, according to the Population and Housing Census of 2009, amounted to 219.6 thousand (enumerated de facto population) or 226.8 thousand (de jure population).[4] The region's estimated population for the beginning of 2021 was 270,994.[2]