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| Formula | C15H16N4O2 |
| Molar mass | 284.319 g·mol−1 |
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Zomebazam[1] produced byHoechst is a pyrazolodiazepinone derivative drug withanxiolytic properties. It is structurally related torazobazam andzometapine.[2]
The catalytic hydrogenation ofN,2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine[a] (1) overRaney nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole[b] (2). Treatment with methyl malonyl chloride[c] (3) gives 4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole[d] (4). Base-catalyzed lactamization gives (5). TheGoldberg reaction completes the synthesis of zomebazam (6).[3][4]
